Antiviral effect of copper chloride on feline calicivirus and synergy with ribavirin in vitro
2020
Dengliang Li | Zhanding Cui | Guohua Li | Liangting Zhang | Ying Zhang | Han Zhao | Shuang Zhang | Yanbing Guo | Yanli Zhao | Fanxing Men | Shihui Zhao | Jiang Shao | Dongju Du | Hailong Huang | Kai Wang | Guixue Hu | Tiansong Li | Yongkun Zhao
Abstract Background Feline calicivirus (FCV) is a common and highly prevalent pathogen causing upper respiratory diseases in kittens and felines in recent years. Due to the substantial genetic variability of the viral genes, existing vaccines cannot provide complete protection. Therefore, research on FCV antiviral drugs has received much attention. Results In this study, we found that copper chloride had dose-dependent antiviral effects on FCV in F81 cells. We also found that the combination of copper chloride and ribavirin had a synergistic protective effect against FCV in F81 cells. In contrast, the combination of copper chloride and horse anti-FCV immunoglobulin F (ab’)2 showed an antagonistic effect, likely because copper chloride has an effect on F (ab’)2 immunoglobulin; however, further research is needed to clarify this supposition. Conclusions In summary, we found that copper chloride had low cytotoxicity and significant antiviral effects on FCV in F81 cells, providing a new drug candidate for the prevention and treatment of FCV infection.
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