Does insulin resistance contribute to the ‘unbrowning’ of brown adipose tissue?
2023
Orien L. Tulp
Historically many patients may present with symptoms suggestive of hypothyroidism or disordered thyroidal parameters, but when the usual labs come back, they often fail to identify any obvious failings in their hypothalamic-thyroidal axis. However, when we turn to the findings in lab rats we may discern the real culprit in the patients’ apparent symptomology. Patients often experiment with any number of a broad assortment of dietary and exercise approaches to resolve their body weight and other issues with little success. Indeed, Laurberg et al. noted that small differences in thyroid function alone have been associated with up to 5 kg difference in body weight.1 Some patients may also experience symptoms of being overly sensitive to dietary carbohydrates, but even after careful monitoring of the types and amounts of carbohydrates consumed, may still often harbor lingering weight control issues but which fall well short of that required for a diagnosis of metabolic syndrome
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