Study of adenosine deaminase and serum protein bound sialic acid levels in alcoholic liver disease

Introduction :- Family history represents the integration of shared genomic and environment risk factors. First degree relatives (IDRs) share half their genomic information and also behaviour, life styles, beliefs, culture and physical environment, so their disease experience may offer a clue to shared susceptibilities. This suggests that a 'low tech' clinical approach-family history-might be a practical and useful way to target interventions and disease prevention efforts to those most at risk The Global Burden of Disease Study projected hypertension as the leading cause of death in the year 2020 .Thus , it is clear that hypertension is an enormous health problem and is one of the biggest health challenge of the 21ST century. Anthropometry provides the single most portable, universally applicable, inexpensive and non-invasive technique for assessing the size, proportions and composition of the human body. Basic anthropometric measurements (weight, height, waist circumference and hip circumference) and their derived indices (body mass index, waist-hip ratio and waist-height ratio) are used as indicators for the presence of diseases and their assessment in clinical practice. This study has been conducted to determine whether such abnormalities can be detected in healthy young adults with a family history of hypertension at an early age that may presage the onset of this chronic disease. Materials and Method:- The present study will be conducted among 200 healthy adults (20-30 years of age) of Amritsar city (100 having family history of hypertension and 100 age matched adults serve as control group).The basic anthropometric measurements of height, weight, hip circumference, waist circumference and the derived indices body mass index (BMI),waist hip ratio (WHR) and waist height ratio(WHtR) were determined from these basic measures. Results:- The various basic and derived anthropometric indices showed changes in healthy adult offspring of the parents with history of hypertension.The results were statistically analysed by using SPSS Software version 17.0 . Conclusion:- All the derived anthropometric indices (BMI,WHR,WHtR) are significantly increased in young healthy adults (20-30yrs of age) having positive family history of hypertension.