Criteria for the development of biological reference materials
1988
Ihnat, M. (Agriculture Canada, Ottawa, Ontario (Canada). Land Resource Research Centre)
A review is presented of factors to be considered in the development of biological reference materials. Some guidelines are offered regarding approaches to the generation of the varied materials required for analytical quality control. Major considerations in such an endeavour are the goal of the undertaking and role of the final product, selection of candidate materials, preparation, characterization and certification. Selection of materials should be from those important to commerce and consumers, and related to various regulatory, clinical, environmental, and research activities. They should adequately represent the different choices and types of foodstuffs, clinical materials and environmental materials, such as soils, sewage sludges, plant and animal tissues, of interest in different regions of the world. Acquisition can be from commercial sources of the result of in-house preparation, with attention to stability enhancement if required and maintenance of native analyte levels by minimization of contamination
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