Identification of the first human gyrovirus, a virus related to chicken anemia virus
2011
Sauvage , Virginie (Institut Pasteur de Paris, Paris(France). Laboratory for Urgent Responses to Biological Threats) | Cheval , Justine (Institut Pasteur de Paris, Paris(France). Pathoquest) | Foulongne , Vincent (Centre Hospitalier Universitaire de Montpellier, Montpellier(France). Laboratoire de Virologie) | Ar Gouilh , Meriadeg (Institut Pasteur de Paris, Paris(France). Laboratory for Urgent Responses to Biological Threats) | Pariente , Kevin (Institut Pasteur de Paris, Paris(France). Laboratory for Urgent Responses to Biological Threats) | Manuguerra , Jean-Claude (Institut Pasteur de Paris, Paris(France). Laboratory for Urgent Responses to Biological Threats) | Richardson , Jennifer (INRA , Maisons-Alfort (France). UMR 1161 Virologie) | Dereure , Olivier (Centre Hospitalier Universitaire de Montpellier, Montpellier(France). Service de Dermatologie) | Lecuit , Marc (Institut Pasteur de Paris, Paris(France). Inserm, Microbes and host barriers Group) | Burguiere , Ana (Institut Pasteur de Paris, Paris(France). Laboratory for Urgent Responses to Biological Threats) | Caro , Valerie (Institut Pasteur de Paris, Paris(France). Genotyping of Pathogens and Public Health Platform) | Eloit , Marc(auteur de correspondance) (INRA , Maisons-Alfort (France). UMR 1161 Virologie)
We have identified in a skin swab sample from a healthy donor a new virus that we have named humangyrovirus (HGyV) because of its similarity to the chicken anemia virus (CAV), the only previously knownmember of the Gyrovirus genus. In particular, this virus encodes a homolog of the CAV apoptin, a protein that selectively induces apoptosis in cancer cells. By PCR screening, HGyV was found in 5 of 115 other nonlesionalskin specimens but in 0 of 92 bronchoalveolar lavages or nasopharyngeal aspirates and in 0 of 92 fecal samples.
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