QTL detection for chicken production and resistance to disease traits

Demeure , Olivier
        INRA
        , Rennes .
         UMR 0598 Génétique Animale; Bacciu , Nicola
        INRA
        , Rennes .
         UMR 0598 Génétique Animale; Carlborg , Örjan
        . Department of Animal Breeding and Genetics; Bovenhuis , H.
        . Animal Breeding and Genomics Centre; De Koning , D.J.
        . The Roslin Institute; Le Bihan , Elisabeth
        INRA
        , Nouzilly .
         UR 0083  Recherches Avicoles; Bed'Hom , Bertrand
        INRA
        , Jouy-En-Josas .
         UMR 1313 Génétique Animale et Biologie Intégrative; Pitel , Frederique
        INRA
        , Auzeville .
         UMR 0444 Laboratoire de Génétique Cellulaire; D'Abbadie , F.
        .; Le Roy , Pascale
        INRA
        , Rennes .
         UMR 0598 Génétique Animale; Pinard Van Der Laan , Marie-Hélène
        INRA
        , Jouy-En-Josas .
         UMR 1313 Génétique Animale et Biologie Intégrative

QTL detection for chicken production and resistance to disease traits

2009

Demeure , Olivier (INRA , Rennes (France). UMR 0598 Génétique Animale) | Bacciu , Nicola (INRA , Rennes (France). UMR 0598 Génétique Animale) | Carlborg , Örjan (Swedish University of Agricultural Science, Uppsala(Suède). Department of Animal Breeding and Genetics) | Bovenhuis , H. (Wageningen University and Research Center, Wageningen(Pays-Bas). Animal Breeding and Genomics Centre) | De Koning , D.J. (University of Edinburgh, Edinburgh(Royaume Uni). The Roslin Institute) | Le Bihan , Elisabeth (INRA , Nouzilly (France). UR 0083 Recherches Avicoles) | Bed'Hom , Bertrand (INRA , Jouy-En-Josas (France). UMR 1313 Génétique Animale et Biologie Intégrative) | Pitel , Frederique (INRA , Auzeville (France). UMR 0444 Laboratoire de Génétique Cellulaire) | D'Abbadie , F. (Société SASSO, 40630 Sabres(France).) | Le Roy , Pascale (INRA , Rennes (France). UMR 0598 Génétique Animale) | Pinard Van Der Laan , Marie-Hélène (INRA , Jouy-En-Josas (France). UMR 1313 Génétique Animale et Biologie Intégrative)

Recently, approaches targeting the whole genome (genome wide selection, GWS) have expanded. However, using an additive model without possible interaction (epistasis) between loci, in particular between the few QTLs which explain a large part of the genetic variance of the traits, would be likely to reduce the efficiency of this strategy. In chickens, coccidiosis susceptibility is an economically important trait which could make the most of GWS. Therefore, we proposed to search for QTLs affecting coccidiosis susceptibility, to test if the selection of this trait could have an impact on production traits and to estimate the extent of the epistasis for all these traits. QTL detection and epistasis estimation are performed on two INRA experimental crosses (900 and 1200 F2 animals phenotyped for coccidiosis susceptibility and composition traits, respectively) genotyped by 1536 SNPs covering most part of the genome. Our aim is to implement these results for MAS or GWS in commercial lines. These lines represent 10 families totalling 1,000 animals which will be genotyped for 384 SNPs targeting the regions identified in the experimental designs. The first results will be presented.

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