Squalamine: an appropriate strategy against the emergence of multidrug resistant gram-negative bacteria?
2008
Salmi , Chanaz | Loncle , Celine | Vidal , Nicolas | Letourneux , Yves (Institut de Recherche pour le Développement, Nouméa (Nouvelle Calédonie). Laboratoire des Substances Naturelles - 98848 Nouméa New Caledonia FR) | Fantini , Jacques (Institut National de la Recherche AgronomiqueCentre National de la Recherche Scientifique, MARSEILLE (France). BBN Biochimie et Biologie de la Nutrition - FRCRN2M Centre de recherche en neurobiologie - neurophysiologie de Marseille - Faculté de Médecine Secteur Nord Boulevard Pierre Dramard 13916 MARSEILLE CEDEX 20 FR) | Maresca , Marc (Centre National de la Recherche Scientifique, MARSEILLE (France). CRN2M Centre de recherche en neurobiologie - neurophysiologie de Marseille - Faculté de Médecine Secteur Nord Boulevard Pierre Dramard 13916 MARSEILLE CEDEX 20 FR) | Taïeb , Nadira (Centre National de la Recherche Scientifique, MARSEILLE (France). CRN2M Centre de recherche en neurobiologie - neurophysiologie de Marseille - Faculté de Médecine Secteur Nord Boulevard Pierre Dramard 13916 MARSEILLE CEDEX 20 FR) | Pagès , Jean-Marie (Universitat de Girona, Girona (Italie). 85259 Universitat de Girona - Plaça Sant Domènec, 1 Edifici les Àligues 17071 Girona IT) | Brunel , Jean Michel (University of Copenhagen, Copenhagen (Danemark). DIKU Department of computer Science [Copenhagen] - University of Copenhagen Department of Computer Science (DIKU) Nørre Campus Universitetsparken 1 DK-2100 Copenhagen Ø Denmark DK)
We reported that squalamine is a membrane-active molecule that targets the membrane integrity as demonstrated by the ATP release and dye entry. In this context, its activity may depend on the membrane lipid composition. This molecule shows a preserved activity against bacterial pathogens presenting a noticeable multi-resistance phenotype against antibiotics such as polymyxin B. In this context and because of its structure, action and its relative insensitivity to efflux resistance mechanisms, we have demonstrated that squalamine appears as an alternate way to combat MDR pathogens and by pass the gap regarding the failure of new active antibacterial molecules.
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