Evolution of some biochemical markers of growth in relation with osteoarticular status in young horses : a longitudinal study in three breeds
2007
Valette, Jean-Paul | Robert, Cédric, | Toquet, M.P. | Denoix, Jean-Marie | Fortier, G.
Osteocalcin (OC), bone fraction of alkaline phosphatases (BAP) and hydroxyproline (HOP) are markers of bone cell activity. The kinetics of these markers and the analysis of their variations could be related to the osteoarticular status (OAS) of young horses. The growth of Thoroughbreds, French Trotters and Selle Français horses was followed up to 18 months. Blood samples were taken regularly to measure OC, HOP and BAP by standardized techniques. The OAS was evaluated by radiographic examination of the limbs. Based on radiographic findings, two groups of horses were investigated, with no lesions or severely affected. Analysis of variance was used to detect the effects of age and breed, and OAS on parameters. The logarithmic model was used to determine the kinetics of the markers. A rapid decrease in marker concentrations with age and differences between breed was observed. At birth, BAP, OC and HOP concentrations were significantly higher in normal horses (1910 UI l− 1, 192 ng ml− 1 and 35 mg l− 1, respectively) than in horses with severe lesions (1620 UI l− 1, 149 ng ml− 1 and 24 mg l− 1, respectively). During the first 6 months, OC, HOP and BAP remained lower in severely affected horses.
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