Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study)
2022
Beauruelle, Clémence | Plouzeau, Chloé | Grillon, Antoine | Isnard, Christophe | Corvec, Stéphane | Degand, Nicolas | Jacquier, Hervé | Amara, Marlène | Mizrahi, Assaf | Diedrich, Tristan | Piau, Caroline | Farfour, Eric | Bonzon, Lucas | Le Brun, Cécile | Walewski, Violaine | Bille, Emmanuelle | Dortet, Laurent | Guillard, Thomas | Soismier, Nathalie | Le Guen, Ronan | Morand, Philippe | de Ponfilly, Gauthier Péan | Le Monnier, Alban | Héry-Arnaud, Geneviève | Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) (GGB) ; EFS-Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM) ; Université de Brest (UBO) | Service de Neurochirurgie [CHU Poitiers] ; Centre hospitalier universitaire de Poitiers (CHU Poitiers) | Virulence Bactérienne Précoce : fonctions cellulaires et contrôle de l'infection aigüe et subaigüe ; Université de Strasbourg (UNISTRA) | Service de pathologie [CHU Strasbourg] ; CHU Strasbourg | Université de Caen Normandie (UNICAEN) ; Normandie Université (NU) | Groupe de Recherche sur les Antimicrobiens et les Micro-Organismes (GRAM 1.0) ; Université de Rouen Normandie (UNIROUEN) ; Normandie Université (NU)-Normandie Université (NU) | Département de pédiatrie [CHU Nantes] ; Centre hospitalier universitaire de Nantes (CHU Nantes) | Laboratoire de Bactériologie [CHU Nice] ; Centre Hospitalier Universitaire de Nice (CHU Nice)-Hôpital Archet 2 [Nice] (CHU) | Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal | Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses [CH Versailles] (CeRéMAIA - Hôpital André Mignot) ; Centre Hospitalier de Versailles André Mignot (CHV) | MICrobiologie de l'ALImentation au Service de la Santé (MICALIS) ; AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Service des Urgences [GH Paris Saint-Joseph] ; Centre hospitalier Saint-Joseph [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) | Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL) ; Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Centre Hospitalier Universitaire de Reims (CHU Reims) | Groupe Hospitalier Paris Saint-Joseph (hpsj)
International audience
Show more [+] Less [-]English. Zoonotic species of Capnocytophaga genus belong to the oral microbiota of dogs and cats. They may be responsible for serious human infections, mainly after animal bites, with a high mortality rate. In France, only few cases have been reported and no multicenter study has been conducted. Our aim was to describe the French epidemiology of Capnocytophaga zoonosis. We conducted a multicenter (21 centers) retrospective non-interventional, observational study in France describing the epidemiology of Capnocytophaga zoonosis (C. canimorsus, C. cynodegmi, C. canis) over 10 years with regard to clinical and bacteriological data. From 2009 to 2018, 44 cases of Capnocytophaga zoonotic infections were described (C. canimorsus, n = 41; C. cynodegmi, n = 3). We observed an increase (2.5 times) in the number of cases over the study period (from the first to the last 5 years of the study). The most frequent clinical presentations were sepsis (n = 37), skin and soft tissue infections (n = 12), meningitis (n = 8), osteoarticular infections (n = 6), and endocarditis (n = 2). About one-third of patients with sepsis went into septic shock. Mortality rate was 11%. Mortality and meningitis rates were significantly higher for alcoholic patients (p = 0.044 and p = 0.006, respectively). Other comorbidities included smoking, splenectomy, diabetes mellitus, and immunosuppressive therapy are associated to zoonotic Capnocytophaga infection. Eighty-two percent of cases involved contact with dogs, mostly included bites (63%). Despite all isolates were susceptible to the amoxicillin-clavulanic acid combination, three of them were resistant to amoxicillin.
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