Perinatal exposure of rats to a maternal diet with varying protein quantity and quality affects the risk of overweight in female adult offspring
2020
Carlin, Gabrielle | Chaumontet, Catherine | Blachier, François | Barbillon, Pierre, M | Darcel, Nicolas, N. | Delteil, Corine | van Der Beek, Eline, M | Kodde, Andrea | van de Heijning, Bert, J M | Tomé, Daniel | Davila-Gay, Anne-Marie, A.-M. | Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)) ; AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Mathématiques et Informatique Appliquées (MIA Paris-Saclay) ; AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Danone Nutricia Research [Utrecht] | University Medical Center Groningen [Groningen] (UMCG) | INRA's DID'IT metaprogram and the ALIAS project managed by INRA and AgroParisTech provided support for the PhD grant and partial financial support for the experimental work. Danone Nutricia Research (DNR) offered partial support for the experimental work.
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Show more [+] Less [-]English. The maternal protein diet during the perinatal period can program the health of adult offspring. This study in rats evaluated the effects of protein quantity and quality in the maternal diet during gestation and lactation on weight and adiposity in female offspring. Six groups of dams were fed a high-protein (HP; 47% protein) or normal-protein (NP; 19% protein) isocaloric diet during gestation (G) using either cow's milk (M), pea (P) or turkey (T) proteins. During lactation, all dams received the NP diet (protein source unchanged). From postnatal day (PND) 28 until PND70, female pups (n=8) from the dam milk groups were exposed to either an NP milk diet (NPM W) or to dietary self-selection (DSS). All other pups were only exposed to DSS. The DSS design was a choice between five food cups containing HPM, HPP, HPT, carbohydrates or lipids. The weights and food intakes of the animals were recorded throughout the study, and samples from offspring were collected on PND70. During the lactation and postweaning periods, body weight was lower in the pea and turkey groups (NP G and HP G) versus the milk group (Pb.0001). DSS groups increased their total energy and fat intakes compared to the NPM W group (Pb.0001). In all HP G groups, total adipose tissue was increased (P=.03) associated with higher fasting plasma leptin (Pb.05). These results suggest that the maternal protein source impacted offspring body weight and that protein excess during gestation, irrespective of its source, increased the risk of adiposity development in female adult offspring.
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