Approaches and perspectives for development of African Swine Fever virus vaccines
2017
Arias, Marisa | de La Torre, Ana | Dixon, Linda | Gallardo, Carmina | Jori, Ferran | Laddomada, Alberto | Martins, Carlos | Michael Parkhouse, R. | Revilla, Yolanda | Rodríguez, Fernando | Sanchez-Vizcaino, Jose-Manuel | Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA) | Pirbright Institute | Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE) ; Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA) | IZS | Universidade de Lisboa = University of Lisbon (ULISBOA) | Instituto Gulbenkian de Ciência | Centro de Biología Molecular Severo Ochoa [Madrid] (CBMSO) ; Consejo Superior de Investigaciones Cientificas = Spanish National Research Council (CSIC)-Universidad Autónoma de Madrid (UAM) | Universitat Autònoma de Barcelona (UAB) | Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM) | European Commision Directorate-General SANTE, Health and Food Safety, throughout the European Union Reference Laboratory Grant 2016-2017
International audience
Show more [+] Less [-]English. African swine fever (ASF) is a complex disease of swine, caused by a large DNA virus belonging to the family Asfarviridae. The disease shows variable clinical signs, with high case fatality rates, up to 100%, in the acute forms. ASF is currently present in Africa and Europe where it circulates in different scenarios causing a high socio-economic impact. In most affected regions, control has not been effective in part due to lack of a vaccine. The availability of an effective and safe ASFV vaccines would support and enforce control-eradication strategies. Therefore, work leading to the rational development of protective ASF vaccines is a high priority. Several factors have hindered vaccine development, including the complexity of the ASF virus particle and the large number of proteins encoded by its genome. Many of these virus proteins inhibit the host's immune system thus facilitating virus replication and persistence. We review previous work aimed at understanding ASFV-host interactions, including mechanisms of protective immunity, and approaches for vaccine development. These include live attenuated vaccines, and subunit vaccines, based on DNA, proteins, or virus vectors. In the shorter to medium term, live attenuated vaccines are the most promising and best positioned candidates. Gaps and future research directions are evaluated.
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