Plant organellar RNA editing: what 30 years of research has revealed
2019
Small, Ian D. | Schallenberg-Ruedinger, Mareike | Takrnaka, Mizuki | Mireau, Hakim | Ostersetzer-Biran, Oren | The University of Western Australia (UWA) | Universität Bonn = University of Bonn | Kyoto University | Institut Jean-Pierre Bourgin (IJPB) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Université Paris Saclay (COmUE) | The Hebrew University of Jerusalem (HUJ) | Israeli Science Foundation' (ISF)Israel Science Foundation [741/15]; German Research Foundation (DFG)German Research Foundation (DFG) [SCHA1952/2-1, SCHA1952/3-1]; Institut National de la Recherche Agronomique (INRA) [UMR 1318]; Agence Nationale de la Recherche (ANR) (MITRA)French National Research Agency (ANR) [ANR-16-CE11-0024-02]; LabEx Saclay Plant Sciences-SPS [ANR-10-LABX-0040-SPS]; JSPSMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [18H02462]; Australian Research CouncilAustralian Research Council [CE140100008, FL140100179] | ANR-16-CE11-0024,MITRA,Caractérisation fonctionnelle et structurale de l'appareil traductionnel mitochondrial chez Arabidopsis thaliana(2016)
International audience
Show more [+] Less [-]English. The central dogma in biology defines the flow of genetic information from DNA to RNA to protein. Accordingly, RNA molecules generally accurately follow the sequences of the genes from which they are transcribed. This rule is transgressed by RNA editing, which creates RNA products that differ from their DNA templates. Analyses of the RNA landscapes of terrestrial plants have indicated that RNA editing (in the form of C-U base transitions) is highly prevalent within organelles (that is, mitochondria and chloroplasts). Numerous C -> U conversions (and in some plants also U -> C) alter the coding sequences of many of the organellar transcripts and can also produce translatable mRNAs by creating AUG start sites or eliminating premature stop codons, or affect the RNA structure, influence splicing and alter the stability of RNAs. RNA-binding proteins are at the heart of post-transcriptional RNA expression. The C-to-U RNA editing process in plant mitochondria involves numerous nuclear-encoded factors, many of which have been identified as pentatricopeptide repeat (PPR) proteins that target editing sites in a sequence-specific manner. In this review we report on major discoveries on RNA editing in plant organelles, since it was first documented 30 years ago.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Institut national de la recherche agronomique
