The hypothalamic arcuate nucleus and the control of peripheral substrates

2014

Joly-Amado, Aurélie | Cansell, Céline | Denis, Raphaël G.P. | Delbes, Anne-Sophie | Castel, Julien | Martinez, Sarah | Luquet, Serge | Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)) ; Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) | This work was supported by young investigator ATIP grant from the CNRS, an equipment grant from the Région Île-de-France, an equipment grant from the University Paris Diderot-Paris 7, a research fellowship from the Société Francophone du Diabète-Lilly and the grant by the “Agence Nationale de la Recherche” ANR-09-BLAN-0267-02 and ANR 11 BSV1 021 01. A.J-A. received a National Merit Scholarship from the French Department of National Education and Research, a research grant from the Société Francophone du Diabète and a research grant from the SFNEP-ANTADIR. R.D. received a research fellowship from the Région Île-de-France. C.C. received a PhD fellowship from the Centre National la Recherche Scientifique (CNRS) and a research grant from the Société Francophone du Diabète-Roche.[1] Molavi B, Rasouli N, Kern PA. The prevention and treatment of metabolic syndrome and high-risk obesity. Curr OpinCardiol 2006;21:479–85.[2] Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000;106:473–81.[3] Kopelman PG, Hitman GA. Diabetes. Exploding type II. Lancet 1998;352(Suppl 4):SIV5.[4] Mokdad AH, Marks JS, Stroup DF, et al. Actual causes of death in the United States, 2000. JAMA: J Am Med Assoc 2004;291:1238–45.[5] Troy S, Soty M, Ribeiro L, et al. Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypassbut not after gastric lap-band in mice. Cell Metab 2008;8:201–11.Practice points Obesity and obesity-related disorders can be separated through central manipulation of ARCneurocircuitry. The establishment and activity of a hypothalamic network can define the equilibrium be-tween carbohydrate and lipid preference | ANR-09-BLAN-0267,gliodiabesity(2009)