Tick-pathogen interactions: The metabolic perspective
2019
Cabezas Cruz, Alejandro | Espinosa, Pedro | Alberdi, Pilar | de La Fuente, José | Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR) ; École nationale vétérinaire - Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie ; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) | SaBio ; Instituto de Investigación en Recursos Cinegéticos (IREC) | Department of Veterinary Pathobiology, Center for Veterinary Health Sciences ; Oklahoma State University [Stillwater] (OSU) | Junta de Comunidades of Castilla-La Mancha (Spain)
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Show more [+] Less [-]English. The first tick genome published in 2016 provided an invaluable tool for studying the molecular basis of tick-pathogen interactions. Metabolism is a key element in host-pathogen interactions. However, our knowledge of tick-pathogen metabolic interactions is very limited. Recently, a systems biology approach, using omics datasets, has revealed that tick-borne pathogen infection induces transcriptional reprograming affecting several metabolic pathways in ticks, facilitating infection, multiplication, and transmission. Results suggest that the response of tick cells to tick-borne pathogens is associated with tolerance to infection. Here we review our current understanding of the modulation of tick metabolism by tick-borne pathogens, with a focus on the model intracellular bacterium <em>Anaplasma phagocytophilum</em>.
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