The human gut microbiome impacts health and disease | Le microbiote intestinal humain influe sur la santé et la maladie
2016
Ehrlich, Stanislas Dusko | MetaGenoPolis ; Institut National de la Recherche Agronomique (INRA) | Metagenopolis grant (ANR-11-DPBS-0001) | ANR-11-DPBS-0001,MGP,MetaGenoPolis(2011)
International audience
Show more [+] Less [-]English. The human gut microbiome can now be characterized in unprecedented detail by an approach based on high-throughput sequencing of total stool DNA, that we name quantitative metagenomics. Central to the approach is a catalog that lists all the genes of intestinal microbes that are known -9.9 millions, identified by the analysis of 1267 stool samples. Beyond the gene list, genetic units that carry them begun to be known; many of these correspond to bacterial species that were never isolated and cultured yet. Quantitative metagenomics allows developing powerful algorithms to diagnose a disease, monitor patients and identify individuals at risk to progress towards a disease. This lays ground for developing new approaches to better restore and even preserve the health by modulation of the altered microbiome, which contributes to promote or aggravate a disease.
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