Nonparticipation Selection Bias in the MOBI-Kids Study
2019
Turner, Michelle | Gracia-Lavedan, Esther | Momoli, Franco | Langer, Chelsea | Castaño-Vinyals, Gemma | Kundi, Michael | Maule, Milena | Merletti, Franco | Sadetzki, Siegal | Vermeulen, Roel | Albert, Alex | Alguacil, Juan | Aragones, Nuria | Badia, Francesc | Bruchim, Revital | Carretero, Gema | Kojimahara, Noriko | Lacour, Brigitte | Morales-Suarez-Varela, Maria | Radon, Katja | Remen, Thomas | Weinmann, Tobias | Yamaguchi, Naohito | Cardis, Elisabeth | Universitat Pompeu Fabra [Barcelona] (UPF) | Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal) | Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health (CIBERESP) | University of Ottawa [Ottawa] | Hospital del Mar Medical Research Institute [Barcelona, Spain] (IMIM) ; Universitat Pompeu Fabra [Barcelona] (UPF) | Medizinische Universität Wien = Medical University of Vienna | Università degli studi di Torino = University of Turin (UNITO) | Sackler Faculty of Medicine ; Tel Aviv University (TAU) | Chaim Sheba Medical Center | Universiteit Utrecht / Utrecht University [Utrecht] | Universidad de Huelva | Ministerio de Sanidad / Ministry of Health [Madrid, Spain] | Tokyo Women's Medical University (TWMU) | Epidemiology of childhood and adolescent cancer | Epidémiologie des cancers de l'enfant et de l'adolescent (EPICEA [CRESS - U1153 / UMR_A 1125]) ; Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques (CRESS (U1153 / UMR_A 1125)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Registre National des Cancers de l'Enfant - National Registry of Childhood Cancers [Villejuif & CHU Nancy] (RNCE) ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Registre National des Tumeurs Solides de l'Enfant (RNTSE) ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy) | Universitat de València = University of Valencia (UV) | Klinikum der Universitat Munchen ; Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München (LMU)
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Show more [+] Less [-]English. Background: MOBI-Kids is a 14-country case-control study designed to investigate the potential effects of electromagnetic field exposure from mobile telecommunications devices on brain tumor risk in children and young adults conducted from 2010 to 2016. This work describes differences in cellular telephone use and personal characteristics among interviewed participants and refusers responding to a brief nonrespondent questionnaire. It also assesses the potential impact of nonparticipation selection bias on study findings.Methods: We compared nonrespondent questionnaires completed by 77 cases and 498 control refusers with responses from 683 interviewed cases and 1501 controls (suspected appendicitis patients) in six countries (France, Germany, Israel, Italy, Japan, and Spain). We derived selection bias factors and estimated inverse probability of selection weights for use in analysis of MOBI-Kids data.Results: The prevalence of ever-regular use was somewhat higher among interviewed participants than nonrespondent questionnaire respondents 10-14 years of age (68% vs. 62% controls, 63% vs. 48% cases); in those 20-24 years, the prevalence was ≥97%. Interviewed controls and cases in the 15- to 19- and 20- to 24-year-old age groups were more likely to have a time since start of use of 5+ years. Selection bias factors generally indicated a small underestimation in cellular telephone odds ratios (ORs) ranging from 0.96 to 0.97 for ever-regular use and 0.92 to 0.94 for time since start of use (5+ years), but varied in alternative hypothetical scenarios considered.Conclusions: Although limited by small numbers of nonrespondent questionnaire respondents, findings generally indicated a small underestimation in cellular telephone ORs due to selective nonparticipation.
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