Validation of QTL affecting resistance to nematodes in Sheep identified in a Back-Cross design in a pure breed population
2014
Moreno-Romieux, Carole | Jacquiet, Philippe, P. | Bouvier, Frédéric, F. | Cortet, Jacques, J. | Blanchard-Letort, Alexandra | Guégnard, Fabrice | Francois, Dominique | Bourdillon, Yves | Grisez, Christelle, C. | Prévot, Françoise, Prevot | Averadere, Audrey | Demars, Julie | Sarry, Julien, J. | Stella, Alessandra | Woloszyn, Florent | Canale-Tabet, Kamila | Cabaret, Jacques, J. | Tosser-Klopp, Gwenola | Sallé, Guillaume, Salle | Génétique Physiologie et Systèmes d'Elevage (GenPhySE) ; Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT) | Interactions hôtes-agents pathogènes [Toulouse] (IHAP) ; Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT) | Domaine expérimental Bourges-La Sapinière (BOURGES) ; Institut National de la Recherche Agronomique (INRA) | Infectiologie et Santé Publique (UMR ISP) ; Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT) | Parco Tecnologico Padano
International audience
Show more [+] Less [-]English. Gastro-intestinal nematodes are of major concern to sheep health worldwide. Identifying the causative genes responsible for resistance would augment the efficiency of selection. Previously, back-cross (BC) sheep (Black Belly * Romane breeds) were genotyped with a 50K SNP chip and were measured for faecal egg count after two successive experimental challenges by H. contortus. The most significant QTL were identified on chromosomes 5, 12, 13, 21. A customized assay including 1000 SNP was created to increase the density ofmarker coverage in these regions and others major QTL regions affecting parasitism resistance in natural infection conditions. In the present study, 277 Romane lambs were experimentally challenged with H contortusand genotyped with the dedicated 1000 SNP. Six out of the eight tested QTL regions have an effect in the Romane pure Breed population.
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