Scientific opinion on flavouring group evaluation 7, revision 5 (FGE.07Rev5): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched‐chain carboxylic acids from chemical group 5
2017
Efsa Panel On Food Contact Materials, Enzymes, Flavourings And Processing Aids (cef), . | Silano, Vittorio | Bolognesi, Claudia | Castle, Laurence | Cravedi, Jean Pierre, J. P. | Engel, Karl‐heinz | Fowler, Paul | Franz, Roland | Grob, Konrad | Gürtler, Rainer | Husøy, Trine | Kärenlampi, Sirpa | Milana, Maria Rosaria | Penninks, André | Tavares Poças, Maria de Fátima | Smith, Andrew | Tlustos, Christina | Wölfle, Detlef | Zorn, Holger | Zugravu, Corina‐aurelia | Beckman Sundh, Ulla | Brimer, Leon | Mosesso, Pasquale | Mulder, Gerard | Anastassiadou, Maria | Mennes, Wim | European Food Safety Authority = Autorité européenne de sécurité des aliments | ToxAlim (ToxAlim) ; Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)
The EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids was requested to evaluate 53 flavouring substances attributed to the Flavouring Group Evaluation 07, including four new substances but-3-en-2-ol, non-l-en-e-ol, hex-l-en-3-one and 1-nonene-3-one [FL-nos: 02.131, 02.187, 07.161 and 07.210] in this Revision 5, using the Procedure in Commission Regulation (EC) No 1565/2000. None of the 53 substances was considered to have genotoxic potential. The substances were evaluated through a stepwise approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold of concern (TTC), and available data on metabolism and toxicity. The Panel concluded that all 53 substances do not give rise to safety concerns at their levels of dietary intake, estimated on the basis of the 'Maximised Survey-derived Daily Intake' (MSDI) approach. Besides the safety assessment of the flavouring substances, the specifications for the materials of commerce have also been considered and found adequate. For 50 substances, further information is required based on comparison of the 'modified Theoretical Added Maximum Daily Intakes' (mTAMDIs) with the TTCs. This would include more reliable intake data and then, if required, additional toxicological data.
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