Phylloquinone (Vitamin K-1): occurrence, biosynthesis and functions
2017
Basset, Gilles | Latimer, Scott | Fatihi, Abdelhak | Soubeyrand, Eric | Block, Anna | Horticultural Sciences Department ; University of Florida [Gainesville] (UF) | Institut Jean-Pierre Bourgin (IJPB) ; Institut National de la Recherche Agronomique (INRA)-AgroParisTech | Université Paris-Saclay | Center for Medical, Agricultural and Veterinary Entomology ; USDA-ARS : Agricultural Research Service | National Science Foundation CAREER [MCB-1148968]
Background: Phylloquinone is a prenylated naphthoquinone that is synthesized exclusively by plants, green algae, and some species of cyanobacteria, where it serves as a vital electron carrier in photosystem I and as an electron acceptor for the formation of protein disulfide bonds. Objective: In humans and other vertebrates, phylloquinone plays the role of a vitamin (vitamin K-1) that is required for blood coagulation and bone and vascular metabolism. Phylloquinone from green leafy vegetables and vegetable oil represents the major dietary source of vitamin K for humans. Method: In recent years, reverse genetics and biochemical approaches using the model plant Arabidopsis thaliana have shown that phylloquinone biosynthesis in plants involves paralogous and multifunctional enzymes, a compartmentation of the corresponding pathway in plastids and peroxisomes, and trafficking of some biosynthetic intermediates within plastids themselves. Furthermore, phylloquinone biosynthetic intermediates create crucial metabolic branch-points with other plastid-synthesized metabolites such as chlorophylls, tocopherols and salicylate. Results & Conclusion: This review presents an update on recent studies of the central role of plastids in the biosynthesis of phylloquinone, in particular on the discovery of novel enzymatic steps that are likely paradigms for phylloquinone and menaquinone (vitamin K-2)-synthesizing organisms alike.
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