Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19
2021
Domingo, Pere | Mur, Isabel | Mateo, Gracia María | Gutierrez, Maria del Mar | Pomar, Virginia | de Benito, Natividad | Corbacho, Noemí | Herrera, Silvia | Millan, Lucia | Muñoz, Jessica | Malouf, Jorge | Molas, Maria Ema | Asensi, Victor | Horcajada, Juan Pablo | Estrada, Vicente | Gutierrez, Felix | Torres, Ferran | Perez-Molina, Jose | Fortun, Jesús | Villar, Luisa | Hohenthal, Ulla | Marttila, Harri | Vuorinen, Tytti | Nordberg, Marika | Valtonen, Mika | Frigault, Matthew | Mansour, Michael | Patel, Naomi | Fernandes, Ana | Harvey, Liam | Foulkes, Andrea | Healy, Brian | Shah, Ruta | Bensaci, Ana Maria | Woolley, Ann | Nikiforow, Sarah | Lin, Nina | Sagar, Manish | Shrager, Harry | Huckins, David | Axelrod, Matthew | Pincus, Michael | Fleisher, Jorge | Lampa, Jon | Nowak, Piotr | Vesterbacka, Jan | Rasmuson, Johan | Skorup, Paul | Janols, Helena | Niward, Katarina | Chatzidionysiou, Katerina | Asgeirsson, Hilmir | Parke, Åsa | Blennow, Ola | Svensson, Anna-Karin | Aleman, Soo | Sönnerborg, Anders | Henter, Jan-Inge | Horne, Anna Carin | Al-Beidh, Farah | Angus, Derek | Annane, Djillali | Arabi, Yaseen | Beane, Abigail | Berry, Scott | Bhimani, Zahra | Bonten, Marc | Bradbury, Charlotte | Brunkhorst, Frank | Buxton, Meredith | Cheng, Allen | Cove, Matt | de Jong, Menno | Derde, Lennie | Estcourt, Lise | Goossens, Herman | Gordon, Anthony | Green, Cameron | Haniffa, Rashan | Ichihara, Nao | Lamontagne, Francois | Lawler, Patrick | Litton, Ed | Marshall, John | Mcarthur, Colin | Mcauley, Daniel | Mcguinness, Shay | Mcverry, Bryan | Montgommery, Stephanie | Mouncey, Paul | Murthy, Srinivas | Nichol, Alistair | Parke, Rachael | Parker, Jane | Reyes, Felipe | Rowan, Kathryn | Saito, Hiroki | Santos, Marlene | Seymour, Chris | Shankar-Hari, Manu | Turgeon, Alexis | Turner, Anne | van Bentum-Puijk, Wilma | van de Veerdonk, Frank | Webb, Steve | Zarychanski, Ryan | Baillie, J Kenneth | Beasley, Richard | Cooper, Nichola | Fowler, Robert | Galea, James | Hills, Thomas | King, Andrew | Morpeth, Susan | Netea, Mihai | Ogungbenro, Kayode | Pettila, Ville | Tong, Steve | Uyeki, Tim | Youngstein, Taryn | Higgins, Alisa | Lorenzi, Elizabeth | Berry, Lindsay | Salama, Carlos | Rosas, Ivan | Ruiz-Antorán, Belén | Muñez Rubio, Elena | Ramos Martínez, Antonio | Campos Esteban, José | Avendaño Solá, Cristina | Pizov, Reuven | Sanz Sanz, Jesus | Abad-Santos, Francisco | Bautista-Hernández, Azucena | García-Fraile, Lucio | Barrios, Ana | Gutiérrez Liarte, Ángela | Alonso Pérez, Tamara | Rodríguez-García, Sebastian | Mejía-Abril, Gina | Prieto, Jose Carlos | Leon, Rafael | Veiga, Viviane | Scheinberg, Phillip | Farias, Danielle L.C. | Prats, João | Cavalcanti, Alexandre | Machado, Flavia | Rosa, Regis | Berwanger, Otávio | Azevedo, Luciano C.P. | Lopes, Renato | Dourado, Leticia | Castro, Claudio | Zampieri, Fernando | Avezum, Alvaro | Lisboa, Thiago | Rojas, Salomón S.O. | Coelho, Juliana | Leite, Rodrigo | Carvalho, Julio Cesar | Andrade, Luis E.C. | Sandes, Alex | Pintão, Maria Carolina T. | Santos, Sueli | Almeida, Thiago M.L. | Costa, André | Gebara, Otavio C.E. | Freitas, Flavio G.R. | Pacheco, Eduardo | Machado, David J.B. | Martin, Josiane | Conceição, Fabio | Siqueira, Suellen R.R. | Damiani, Lucas | Ishihara, Luciana | Schneider, Daniel | de Souza, Denise | Hermine, Olivier | Mariette, Xavier | Tharaux, Pierre Louis | Resche Rigon, Matthieu | Porcher, Raphael | Ravaud, Philippe | Azoulay, Elie | Cadranel, Jacques | Emmerich, Joseph | Fartoukh, Muriel | Guidet, Bertrand | Humbert, Marc | Lacombe, Karine | Mahevas, Matthieu | Pene, Frédéric | Pourchet-Martinez, Valérie | Schlemmer, Frédéric | Tibi, Annick | Yazdanpanah, Yazdan | Dougados, Maxime | Bureau, Serge | Horby, Peter | Landray, Martin | Baillie, Kenneth | Buch, Maya | Chappell, Lucy | Day, Jeremy | Faust, Saul | Haynes, Richard | Jaki, Thomas | Jeffery, Katie | Juszczak, Edmund | Lim, Wei Shen | Mafham, Marion | Montgomery, Alan | Mumford, Andrew | Thwaites, Guy | Kamarulzaman, Adeeba | Syed Omar, Sharifah Faridah | Ponnampalavanar, Sasheela | Raja Azwa, Raja Iskandar Syah | Wong, Pui Li | Kukreja, Anjanna | Ong, Hang Cheng | Sulaiman, Helmi | Basri, Sazali | Ng, Rong Xiang | Megat Johari, Bushra | Rajasuriar, Reena | Chong, Meng Li | Neelamegam, Malinee | Syed Mansor, Syed Mukhtar | Zulhaimi, Nurul Syuhada | Lee, Cheng Siang | Altice, Frederick | Price, Christina | Malinis, Maricar | Hasan, Mohd Shahnaz | Wong, Chee Kuan | Chidambaram, Suresh | Misnan, Nor Arisah | Mohd Thabit, Alif Adlan | Sim, Benedict | Bidin, Farah Nadiah | Mohd Abd Rahim, Mohd Abd Hafiz | Saravanamuttu, Sujana | Tuang, Wei Xuan | Mohamed Gani, Yasmin | Thangavelu, Suvintheran | Tay, Kim Heng | Ibrahim, Nur Munirah | Halid, Luqman Alhakim | Tan, Kok Tong | Mukri, Mohd Noor Azreet | Arip, Masita | Koh, Hui Moon | Syed Badaruddin, Syarifah Nurul Ain | Raja Sureja, Letchumi | Chun, Geok Ying | Torre-Cisneros, Julian | Merchante, Nicolas | Leon, Rafael | Carcel, Sheila | Garrido, Jose Carlos | Galun, Eitan | Soriano, Alex | Martínez, José Antonio | Castán, Clara | Paredes, Roger | Dalmau, David | Carbonell, Cristina | Espinosa, Gerard | Castro, Pedro | Muñóz, José | Almuedo, Alex | Prieto, Sergio | Pacheco, Iván | Ratain, Mark | Pisano, Jennifer | Strek, Mary | Adegunsoye, Ayodeji | Karrison, Theodore | Jozefien, Declercq | Karel F.A., van Damme | Elisabeth, de Leeuw | Cedric, Bosteels | Bastiaan, Maes | Shankar-Hari, Manu | Vale, Claire | Godolphin, Peter | Fisher, David | Higgins, Julian | Spiga, Francesca | Savovic, Jelena | Tierney, Jayne | Baron, Gabriel | Benbenishty, Julie | Berry, Lindsay | Broman, Niklas | Cavalcanti, Alexandre Biasi | Colman, Roos | de Buyser, Stefanie | Derde, Lennie | Domingo, Pere | Omar, Sharifah Faridah | Fernandez-Cruz, Ana | Feuth, Thijs | Garcia, Felipe | Garcia-Vicuna, Rosario | Gonzalez-Alvaro, Isidoro | Gordon, Anthony | Haynes, Richard | Hermine, Olivier | Horby, Peter | Horick, Nora | Kumar, Kuldeep | Lambrecht, Bart | Landray, Martin | Leal, Lorna | Lederer, David | Lorenzi, Elizabeth | Mariette, Xavier | Merchante, Nicolas | Misnan, Nor Arisah | Mohan, Shalini | Nivens, Michael | Oksi, Jarmo | Perez-Molina, Jose | Pizov, Reuven | Porcher, Raphael | Postma, Simone | Rajasuriar, Reena | Ramanan, Athimalaipet | Ravaud, Philippe | Reid, Pankti | Rutgers, Abraham | Sancho-Lopez, Aranzazu | Seto, Todd | Sivapalasingam, Sumathi | Soin, Arvinder Singh | Staplin, Natalie | Stone, John | Strohbehn, Garth | Sunden-Cullberg, Jonas | Torre-Cisneros, Julian | Tsai, Larry | van Hoogstraten, Hubert | van Meerten, Tom | Veiga, Viviane Cordeiro | Westerweel, Peter | Murthy, Srinivas | Diaz, Janet | Marshall, John | Sterne, Jonathan | Hospital de la Santa Creu i Sant Pau | Instituto de Salud Carlos III [Madrid] (ISCIII) | Universidad de Oviedo = University of Oviedo | Hospital Universitario de Elche | Universitat de Barcelona (UB) | Massachusetts General Hospital [Boston] | Harvard Medical School [Boston] (HMS) | Methods of therapeutic evaluation of chronic diseases | Méthodes de l’évaluation thérapeutique des maladies chroniques (METHODS [CRESS - U1153 / UMR_A 1125]) ; Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques (CRESS (U1153 / UMR_A 1125)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Centre d'épidémiologie Clinique [Hôtel-Dieu] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Hôtel Dieu | Columbia Mailman School of Public Health ; Columbia University [New York]
International audience
Show more [+] Less [-]English. Abstract Objectives In France, about 30% of the population refuses COVID-19 vaccination outright, and 9 to 40% are hesitant. We developed and evaluated an interactive web tool providing transparent and reliable information on the benefits and risks of COVID-19 vaccination. Methods The most recent scientific data at the time of the study were implemented into an interactive web tool offering individualized information on the risks of COVID-19 infection-related events versus vaccination-related serious adverse events. The tool was evaluated during a before-and-after impact study nested in ComPaRe, a French e-cohort of adult patients with chronic conditions. Primary outcome was the proportion of patients intending to receive vaccination after using the tool, among those not intending to receive it at baseline. Results Between January 8 and 14, 2021, we enrolled 3152 patients in the study [mean age 55.2 (SD: 16.9), 52.9% women and 63% with ≥ 2 chronic conditions]. Before consulting the tool, 961 (30.5%) refused to be vaccinated until further data on efficacy/safety was obtained and 239 (7.5%) outright refused vaccination. Among these 1200 patients, 96 (8.0%, number needed to treat: 12.5) changed their mind after consulting the tool and would subsequently accept vaccination. Conclusions Our interactive web tool represents a scalable method to help increase the intent to receive COVID-19 vaccination among patients with chronic conditions and address vaccine hesitancy. Since April 2021, our tool has been embedded on the official webpage of the French Government for COVID-19 information.
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