Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
2021
Everson, Todd M. | Vives-Usano, Marta | Seyve, Emie | Cardenas, Andres | Lacasana, Marina | Craig, Jeffrey M. | Lesseur, Corina | Baker, Emily R. | Fernandez-Jimenez, Nora | Heude, Barbara | Perron, Patrice | Gonzalez-Alzaga, Beatriz | Halliday, Jane | Deyssenroth, Maya A. | Karagas, Margaret R. | Iniguez, Carmen | Bouchard, Luigi | Carmona-Saez, Pedro | Loke, Yuk J. | Hao, Ke | Belmonte, Thalia | Charles, Marie A. | Martorell-Marugan, Jordi | Muggli, Evelyne | Chen, Jia | Fernandez, Mariana F. | Tost, Jorg | Gomez-Martin, Antonio | London, Stephanie J. | Sunyer, Jordi | Marsit, Carmen J. | Lepeule, Johanna | Hivert, Marie-France | Bustamante, Mariona | Emory University [Atlanta, GA] | Center for Genomic Regulation (CRG-UPF) ; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health (CIBERESP) | Barcelona Institute of Science and Technology (BIST) | Universitat Pompeu Fabra [Barcelona] (UPF) | Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB) ; Centre Hospitalier Universitaire [CHU Grenoble] (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA) | Harvard Medical School [Boston] (HMS) | School of Public Health [Berkeley] ; University of California [Berkeley] (UC Berkeley) ; University of California (UC)-University of California (UC) | Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health (CIBERESP) | Andalusian School of Public Health [Granada] | Murdoch Children's Research Institute (MCRI) | Department of Paediatrics [Melbourne] ; Melbourne Medical School [Melbourne] ; Faculty of Medicine, Dentistry and Health Sciences [Melbourne] ; University of Melbourne-University of Melbourne-Faculty of Medicine, Dentistry and Health Sciences [Melbourne] ; University of Melbourne-University of Melbourne | Deakin University [Burwood] | Icahn School of Medicine at Mount Sinai [New York] (MSSM) | Geisel School of Medicine at Dartmouth | Universidad del País Vasco [Espainia] / Euskal Herriko Unibertsitatea [España] = University of the Basque Country [Spain] = Université du pays basque [Espagne] (UPV / EHU) | Biocruces Bizkaia Health Research Institute [Baracaldo] | Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques (CRESS (U1153 / UMR_A 1125)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Université de Sherbrooke (UdeS) | Universitat de València = University of Valencia (UV) | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne] (FISABIO) | Universitat Jaume I = Jaume I University | Department of Biochemistry and Functional Genomics ; Université de Sherbrooke (UdeS) | Universidad de Granada = University of Granada (UGR) | Universidad de Oviedo = University of Oviedo | Laboratoire Epigénétique et environnement (LEE) ; Centre National de Recherche en Génomique Humaine (CNRGH) ; Institut de Biologie François JACOB (JACOB) ; Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Biologie François JACOB (JACOB) ; Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) | Centre National de Recherche en Génomique Humaine (CNRGH) ; Institut de Biologie François JACOB (JACOB) ; Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) | National Institute of Environmental Health Sciences [Durham, NC, USA] (NIEHS-NIH) ; National Institutes of Health [Bethesda, MD, USA] (NIH) | Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal) | IMIM-Hospital del Mar ; Generalitat de Catalunya = Generalidad de Cataluña = Government of Catalonia = Généralité de Catalogne | Massachusetts General Hospital [Boston] | the National Institutes of Health
International audience
Show more [+] Less [-]English. Maternal smoking during pregnancy (MSDP) contributes to poor birth outcomes, in part through disrupted placental functions, which may be reflected in the placental epigenome. Here we present a meta-analysis of the associations between MSDP and placental DNA methylation (DNAm) and between DNAm and birth outcomes within the Pregnancy And Childhood Epigenetics (PACE) consortium (N = 1700, 344 with MSDP). We identify 443 CpGs that are associated with MSDP, of which 142 associated with birth outcomes, 40 associated with gene expression, and 13 CpGs are associated with all three. Only two CpGs have consistent associations from a prior meta-analysis of cord blood DNAm, demonstrating substantial tissue-specific responses to MSDP. The placental MSDP-associated CpGs are enriched for environmental response genes, growth-factor signaling, and inflammation, which play important roles in placental function. We demonstrate links between placental DNAm, MSDP and poor birth outcomes, which may better inform the mechanisms through which MSDP impacts placental function and fetal growth.
Show more [+] Less [-]Bibliographic information
This bibliographic record has been provided by Institut national de la recherche agronomique