Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
2023
Cannarella, Rossella | Shah, Rupin | Hamoda, Taha Abo-Almagd Abdel-Meguid | Boitrelle, Florence | Saleh, Ramadan | Gul, Murat | Rambhatla, Amarnath | Kavoussi, Parviz | Toprak, Tuncay | Harraz, Ahmed, M | Ko, Edmund | Çeker, Gökhan | Durairajanayagam, Damayanthi | Alkahidi, Noora | Kuroda, Shinnosuke | Crafa, Andrea | Henkel, Ralf | Salvio, Gianmaria | Hazir, Berk | Darbandi, Mahsa | Bendayan, Marion | Darbandi, Sara | Falcone, Marco | Garrido, Nicolas | Kosgi, Raghavender | Sawaid Kaiyal, Raneen, Sawaid | Karna, Keshab | Phuoc, Nguyen, Ho Vinh | Birowo, Ponco | Colpi, Giovanni, M | de la Rosette, Jean | Pinggera, Germar-Michael | Nguyen, Quang | Zini, Armand | Zohdy, Wael | Singh, Rajender | Saini, Pallavi | Glina, Sidney | Lin, Haocheng | Mostafa, Taymour | Rojas-Cruz, Cesar | Arafa, Mohamed | Calogero, Aldo, E | Dimitriadis, Fotios | Kothari, Priyank | Karthikeyan, Vilvapathy, Senguttuvan | Okada, Keisuke | Chiba, Koji | Kadıoglu, Ates | Altay, Baris | Turunc, Tahsin | Zilaitiene, Birute | Gokalp, Fatih | Adamyan, Aram | Katz, Darren | Chung, Eric | Mierzwa, Tiago, Cesar | Zylbersztejn, Daniel, Suslik | Paul, Gustavo, Marquesine | Sofikitis, Nikolaos | Sokolakis, Ioannis | Malhotra, Vineet | Brodjonegoro, Sakti, Ronggowardhana | Adriansjah, Ricky | Tsujimura, Akira | Amano, Toshiyasu | Balercia, Giancarlo | Ziouziou, Imad | Deswanto, Isaac, Ardianson | Martinez, Marlon | Park, Hyun, Jun | Bakırcıoglu, Mustafa, Emre | Ceyhan, Erman | Aydos, Kaan | Ramsay, Jonathan | Minhas, Suks | Hashimi, Manaf, Al | Ghayda, Ramy, Abou | Tadros, Nicholas | Sindhwani, Puneet | Ho, Christopher, C K | Rachman, Rinaldo, Indra | Rodriguez Pena, Marcelo | Motawi, Ahmad | Ponnusamy, Arun, Karthik | Dipankar, Satish | Amir, Azwar | Binsaleh, Saleh | Serefoglu, Ege, Can | Banthia, Ravi | Khalafalla, Kareim | Basukarno, Ari | Bac, Nguyen, Hoai | Singla, Karun | Ambar, Rafael, F | Makarounis, Konstantinos | Priyadarshi, Shivam | Duarsa, Gede, Wirya Kusuma | Atmoko, Widi | Jindal, Sunil | Arianto, Eko | Akhavizadegan, Hamed | El Bardisi, Haitham | Shoshany, Ohad | Busetto, Gian, Maria | Moussa, Mohamad | Jamali, Mounir | Al-Marhoon, Mohamed, S | Ruzaev, Mikhail | Farsi, Hasan, M A | Mutambirwa, Shingai | Lee, Dong, Sup | Kulaksiz, Deniz | Cheng, Yu-Sheng | Bouzouita, Abderrazak | Sarikaya, Selcuk | Kandil, Hussein | Tsampoukas, Georgios | Farkouh, Ala’a | Bowa, Kasonde | Savira, Missy | Mogharabian, Nasser | Le, Tan, V | Harjanggi, Maruto | Anh, Dang, Tuan | Long, Tran, Quang Tien | Soebadi, Mohammad, Ayodhia | Hakim, Lukman | Tanic, Marko | Ari, Umut, Cagin | Parikh, Firuza, R | Calik, Gokhan | Kv, Vinod | Dorji, Gyem | Rezano, Andri | Rajmil, Osvaldo | Tien, Dung, Mai Ba | Yuan, Yiming | Lizarraga-Salas, Juan, Francisco | Eze, Balantine | Ngoo, Kay, Seong | Lee, Joe | Arslan, Umut | Agarwal, Ashok | Università degli studi di Catania = University of Catania (Unict) | Cleveland Clinic | Lilavati Hospital and Research Centre | King Abdulaziz University | Minia University | CHI Poissy-Saint-Germain | Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED) ; École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Sohag University | Faculty of Medicine [Selcuk University Konya, Turkey] ; Selçuk University = Selçuk Üniversitesi | Vattikuti Urology Institute ; Henry Ford Hospital | İstanbul Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi | Mansoura University [Egypt] | Loma Linda University | Universiti Teknologi MARA [Shah Alam] (UiTM) | Yokohama City University (YCU) | Imperial College London | Polytechnic University of Marche / Università Politecnica delle Marche (UNIVPM) | Skane University Hospital [Lund] | Hope Generation Foundation | Molinette Hospital | University of Massachusetts Medical School [Worcester] (UMASS) ; University of Massachusetts System (UMASS) | University of Medicine Pham Ngoc Thach | Universitas Indonesia (UI) | Istanbul Medipol University | Innsbruck Medical University = Medizinische Universität Innsbruck (IMU) | Vietnam National University [Hanoï] (VNU) | McGill University = Université McGill [Montréal, Canada] | Cairo University | Peking University [Beijing] | University Hospital Rostock | Hamad medical corporation | Weill Cornell Medicine [Qatar] | Aristotle University of Thessaloniki | Apollo Hospital, Bilaspur(C. G.), India | Kobe University | Istanbul University | Ege university [Izmir, Turkey] | Hatay Mustafa Kemal University | University of Melbourne | The University of Queensland (UQ [All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations]) | Hospital Israelita Albert Einstein [São Paulo, Brazil] | Universidade Federal do Paraná [Curitiba, Brasil] = Federal University of Paraná [Curitiba, Brazil] = Université fédérale du Paraná [Curitiba, Brésil] (UFPR) | University of Ioannina | Gadjah Mada University = Universitas Gadjah Mada (UGM) | Universitas Padjadjaran = Padjadjaran University (UnPad) | Juntendo University | Université Ibn Zohr = Ibn Zohr University [Agadir] | University of Santo Tomas [Manila, Philippines] | Pusan National University (PNU) | Ankara University School of Medicine [Turkey] | Hammersmith Hospital NHS Imperial College Healthcare | Burjeel Hospital | Case Western Reserve University [Cleveland] | Southern Illinois University School of Medicine | University of Toledo | Taylor’s University | King Saud University [Riyadh] (KSU) | Biruni University | Western General Hospital [Edinburgh, UK] | Hamad Medical Corporation [Doha, Qatar] | McGovern Medical School [Houston, Texas] ; The University of Texas Health Science Center at Houston (UTHealth) | MD Anderson Cancer Center [Houston] ; The University of Texas Health Science Center at Houston (UTHealth) | Hanoï Medical University | Tehran University of Medical Sciences (TUMS) | University of Illinois [Chicago] (UIC) ; University of Illinois System | Università degli Studi di Foggia = University of Foggia (Unifg) | الجامعة اللبنانية [بيروت] = Lebanese University [Beirut] = Université libanaise [Beyrouth] (LU / ULB) | Sultan Qaboos University (SQU) | Sefako Makgatho Health Sciences University [South-Africa] = Université des sciences de la santé Sefako Makgatho [Afrique du Sud] (MEDUNSA / SMU) | Catholic University of Korea | National Cheng Kung University (NCKU) | Faculte De Medecine De Tunis, Universite De Tunis El Manar, LR18ES39, Tunis, Tunisia | John Radcliffe Hospital [Oxford University Hospital] | University of Zambia [Lusaka] (UNZA) | Shahroud University of Medical Sciences | Universitas Airlangga (UNAIR) | Kafkas Üniversitesi - Kafkas University | Jaslok Hospital & Research Centre | Fundació Puigvert [Barcelona, Spain] | Department of Medical Biochemistry, College of Medicine, University of Nigeria, Enugu Campus (UNEC) Enugu, Nigeria | National University Hospital Singapore
International audience
Show more [+] Less [-]English. Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles.Materials and methods: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies).Results: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864.Conclusions: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by Institut national de la recherche agronomique