Antimicrobial ionic liquid‐based materials for biomedical applications
2021
Nikfarjam, Nasser | Ghomi, Matineh | Agarwal, Tarun | Hassanpour, Mahnaz | Sharifi, Esmaeel | Khorsandi, Danial | Ali Khan, Moonis | Rossi, Filippo | Rossetti, Arianna | Nazarzadeh Zare, Ehsan | Rabiee, Navid | Afshar, Davoud | Vosough, Massoud | Kumar Maiti, Tapas | Mattoli, Virgilio | Lichtfouse, Eric | Tay, Franklin, R | Makvandi, Pooyan | Institute for Advanced Studies in Basic Sciences (IASBS) | Shahid Chamran University of Ahvaz (SCU) | Indian Institute of Technology Kharagpur (IIT Kharagpur) | Hamadan University of Medical Sciences | Universitat de Barcelona (UB) | King Saud University [Riyadh] (KSU) | Politecnico di Milano [Milan] (POLIMI) | Damghan University | Institut Pasteur d'Iran ; Pasteur Network (Réseau International des Instituts Pasteur) | Zanjan University of Medical Sciences | Royan Institute for Stem Cell Biology and Technology | Italian Institute of Technology = Istituto Italiano di Tecnologia (IIT) | Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement (CEREGE) ; Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Xi'an Jiaotong University (Xjtu) | Augusta University ; University System of Georgia (USG)
International audience
Show more [+] Less [-]English. Excessive and unwarranted administration of antibiotics has invigorated the evolution of multidrug-resistant microbes. There is, therefore, an urgent need for advanced active compounds. Ionic liquids with short-lived ion-pair structures are highly tunable and have diverse applications. Apart from their unique physicochemical features, the newly discovered biological activities of ionic liquids have fascinated biochemists, microbiologists, and medical scientists. In particular, their antimicrobial properties have opened new vistas in overcoming the current challenges associated with combating antibiotic-resistant pathogens. Discussions regarding ionic liquid derivatives in monomeric and polymeric forms with antimicrobial activities are presented here. The antimicrobial mechanism of ionic liquids and parameters that affect their antimicrobial activities, such as chain length, cation/anion type, cation density, and polymerization, are considered. The potential applications of ionic liquids in the biomedical arena, including regenerative medicine, biosensing, and drug/biomolecule delivery, are presented to stimulate the scientific community to further improve the antimicrobial efficacy of ionic liquids.
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