Risk of neuroblastoma, birth-related characteristics, congenital ă malformations and perinatal exposures: A pooled analysis of the ESCALE ă and ESTELLE French studies (SFCE)
2016
Rios, Paula | Bailey, Helen D. | Orsi, Laurent | Lacour, Brigitte | Valteau-Couanet, Dominique | Levy, Dominique | Corradini, Nadège | Leverger, Guy | Defachelles, Anne-Sophie | Gambart, Marion | Sirvent, Nicolas | Thébaud, Estelle | Ducassou, Stéphane | Clavel, Jacqueline | Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)) ; Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Registre National des Tumeurs Solides de l'Enfant (RNTSE) ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Cancéropôle du Grand Est | Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy] ; Institut Gustave Roussy (IGR) | Paris School of Economics (PSE) ; Université Paris 1 Panthéon-Sorbonne (UP1)-École normale supérieure - Paris (ENS-PSL) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-École des hautes études en sciences sociales (EHESS)-École nationale des ponts et chaussées (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Paris-Jourdan Sciences Economiques (PSE) ; École normale supérieure - Paris (ENS-PSL) ; Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-École des hautes études en sciences sociales (EHESS)-École nationale des ponts et chaussées (ENPC)-Centre National de la Recherche Scientifique (CNRS) | Centre Léon Bérard [Lyon] | Hôpital Trousseau ; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours) | Service de Pédiatrie, Unité d'Oncologie et Hématologie Pédiatrique ; Centre Hospitalier Universitaire de Nice (CHU Nice) | Service d'oncologie pédiatrique [Nantes] ; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes) | Hôpital Pellegrin ; Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux)-Groupe hospitalier Pellegrin
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Show more [+] Less [-]English. Neuroblastoma (NB), an embryonic tumour arising from neural crest cells, ă is the most common malignancy among infants. The aetiology of NB is ă largely unknown. We conducted a pooled analysis to explore whether there ă is an association between NB and preconception and perinatal factors ă using data from two French national population-based case-control ă studies. The mothers of 357 NB cases and 1783 controls younger than 6 ă years, frequency-matched by age and gender, responded to a telephone ă interview that focused on demographic, socioeconomic and perinatal ă characteristics, childhood environment, life-style and maternal ă reproductive history. Unconditional logistic regression was used to ă estimate pooled odds ratios and 95% confidence intervals. After ă controlling for matching variables, study of origin and potential ă confounders, being born either small (OR 1.4 95% CI 1.0-2.0) or large ă (OR 1.5 95% CI 1.1-2.2) for gestational age and, among children younger ă than 18 months, having congenital malformations (OR 3.6 95% CI ă 1.3-8.9), were significantly associated with NB. Inverse associations ă were observed with breastfeeding (OR 0.7 95% CI 0.5-1.0) and maternal ă use of any supplements containing folic acid, vitamins or minerals (OR ă 0.5 95% CI 0.3-0.9) during the preconception period. Our findings ă reinforce the hypothesis that fetal growth anomalies and congenital ă malformations may be associated with an increased risk of NB. Further ă investigations are needed in order to clarify the role of folic acid ă supplementation and breastfeeding, given their potential importance in ă NB prevention.
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