Weevil pgrp-lb prevents endosymbiont TCT dissemination and chronic host systemic immune activation
2019
Maire, Justin | Vincent-Monégat, Carole | Balmand, Severine | Vallier, Agnès | Hervé, Mireille | Le Masson, Florent | Parisot, Nicolas | Vigneron, Aurélien | Anselme, Caroline | Perrin, Jackie | Orlans, Julien | Rahioui, Isabelle | da Silva, Pedro | Fauvarque, Marie-Odile | Mengin-Lecreulx, Dominique | Zaidman-Remy, Anna | Heddi, Abdelaziz | Biologie Fonctionnelle, Insectes et Interactions (BF2I) ; Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées de Lyon (INSA Lyon) ; Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA) | Institut de Biologie Intégrative de la Cellule (I2BC) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) | Institut National de la Recherche Agronomique; Institut National des Sciences Appliquees-Lyon; French (IMetSym) [ANR-13-BSV7-0016-01]; French (GREEN) [ANR-17-CE20-0031-01]; La Region Rhone-Alpes | ANR-17-CE20-0031,GREEN,Comprendre les mécanismes de régulation et la fonction des gènes de la réponse immunitaire de l'hôte pour perturber la symbiose et le contrôle des endosymbiotes chez les insectes nuisibles(2017)
International audience
Show more [+] Less [-]English. Significance Permanent infections with beneficial bacteria are widespread in nature and are believed to play a pivotal role in evolution. How hosts’ immune functions are regulated to maintain cooperative bacteria while preventing them from constantly activating the host immune system is a key question in understanding host–bacterial associations’ sustainability. In insects, beneficial bacteria are often confined within specialized host cells, the bacteriocytes, which avoid direct contact between the host’s immune system and bacteria. Here, we report an additional mechanism that prevents bacteria-released immunogenic molecules (i.e., peptidoglycan fragments) from escaping the bacteriocytes. We show that two peptidoglycan-cleaving enzymes are specifically produced in the bacteriocytes, where they cleave bacterial peptidoglycan into nonimmunogenic fragments, thereby preventing continuous and damageable host systemic immune activation.
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