DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation
2022
Quaglia, Federica | Mészáros, Bálint | Salladini, Edoardo | Hatos, András | Pancsa, Rita | Chemes, Lucía, B | Pajkos, Mátyás | Lazar, Tamas | Peña-Díaz, Samuel | Santos, Jaime | Ács, Veronika | Farahi, Nazanin | Fichó, Erzsébet | Aspromonte, Maria, Cristina | Bassot, Claudio | Chasapi, Anastasia | Davey, Norman, E | Davidović, Radoslav | Dobson, Laszlo | Elofsson, Arne | Erdős, Gábor | Gaudet, Pascale | Giglio, Michelle | Glavina, Juliana | Iserte, Javier | Iglesias, Valentín | Kálmán, Zsófia | Lambrughi, Matteo | Leonardi, Emanuela | Longhi, Sonia | Macedo-Ribeiro, Sandra | Maiani, Emiliano | Marchetti, Julia | Marino-Buslje, Cristina | Mészáros, Attila | Monzon, Alexander, Miguel | Minervini, Giovanni | Nadendla, Suvarna | Nilsson, Juliet, F | Novotný, Marian | Ouzounis, Christos, A | Palopoli, Nicolás | Papaleo, Elena | Pereira, Pedro, José Barbosa | Pozzati, Gabriele | Promponas, Vasilis, J | Pujols, Jordi | Rocha, Alma, Carolina Sanchez | Salas, Martin | Sawicki, Luciana, Rodriguez | Schad, Eva | Shenoy, Aditi | Szaniszló, Tamás | Tsirigos, Konstantinos, D | Veljkovic, Nevena | Parisi, Gustavo | Ventura, Salvador | Dosztányi, Zsuzsanna | Tompa, Peter | Tosatto, Silvio, C E | Piovesan, Damiano | Università degli Studi di Padova = University of Padua (Unipd) | European Molecular Biology Laboratory [Heidelberg] (EMBL) | Research Centre for Natural Sciences ; Hungarian Academy of Sciences (MTA) | Universidad Nacional de San Martin (UNSAM) | Eötvös Loránd University (ELTE) | Vrije Universiteit Brussel [Bruxelles] (VUB) | Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona (UAB) | Stockholm University | Centre for Research and Technology Hellas (CERTH) | Chester Beatty Laboratories | University of Belgrade [Belgrade] | Swiss Institute of Bioinformatics [Genève] (SIB) | University of Maryland School of Medicine ; University System of Maryland | Fundación Instituto Leloir [Buenos Aires] | Pázmány Péter Catholic University | Danish Cancer Society Research Center | Architecture et fonction des macromolécules biologiques (AFMB) ; Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Universidade do Porto = University of Porto | Universidad Nacional de Quilmes (UNQ) | Faculty of Science | Aristotle University of Thessaloniki | Danmarks Tekniske Universitet = Technical University of Denmark (DTU) | University of Cyprus [Nicosia] (UCY) | Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] (UK) | Wellcome Trust Genome Campus | Italian Ministry of University and Research (MIUR), PRIN 2017 under grant agreement no. 2017483NH8. | European Project: 778247,IDPfun
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Show more [+] Less [-]English. The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.
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