A physico-genetic module for the polarisation of auxin efflux carriers PIN-FORMED (PIN)
2018
Hernandez, Valéria | Barrio, Rafael A. | Benitez, Mariana | Nakayama, Naomi | Roberto Romero-Arias, Jose | Villarreal, Carlos | Reproduction et développement des plantes (RDP) ; École normale supérieure de Lyon (ENS de Lyon) ; Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) ; Université de Lyon-Centre National de la Recherche Scientifique (CNRS) | Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM) | Instituto de Física (IF-UNAM) ; Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM) | The University of Edinburgh | Universidad Michoacana de San Nicolás de Hidalgo (UMICH) | CONACyT; DGAPA; CONACyT [180380]; University of Edinburgh Chancellor's Fellowship; Royal Society University Research Fellowship; FORDECyT [265667]
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Show more [+] Less [-]English. Intracellular polarisation of auxin efflux carriers is crucial for understanding how auxin gradients form in plants. The polarisation dynamics of auxin efflux carriers PIN-FORMED (PIN) depends on both biomechanical forces as well as chemical, molecular and genetic factors. Biomechanical forces have shown to affect the localisation of PIN transporters to the plasma membrane. We propose a physico-genetic module of PIN polarisation that integrates biomechanical, molecular, and cellular processes as well as their non-linear interactions. The module was implemented as a discrete Boolean model and then approximated to a continuous dynamic system, in order to explore the relative contribution of the factors mediating PIN polarisation at the scale of single cell. Our models recovered qualitative behaviours that have been experimentally observed and enable us to predict that, in the context of PIN polarisation, the effects of the mechanical forces can predominate over the activity of molecular factors such as the GTPase ROP6 and the ROP-INTERACTIVE CRIB MOTIF-CONTAINING PROTEIN RIC1.
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