[¹²³I]ICF01012 melanoma imaging and [¹³¹I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models
2015
Viallard, Claire | Perrot, Yann | Boudhraa, Zied | Jouberton, Elodie | Miot-Noirault, Elisabeth | Bonnet, Mathilde | Besse, Sophie | Mishellany, Florence | Cayre, Anne | Maigne, Lydia | Rbah-Vidal, Latifa | D’incan, Michel | Cachin, Florent | Chezal, Jean-Michel, J.-M. | Degoul, Francoise | Imagerie Moléculaire et Thérapie Vectorisée (IMTV) ; Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Cancéropôle CLARA-ITMO " Technologies pour la Santé " | Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC) ; Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) | Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP) ; UNICANCER | Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH) ; Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)
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Show more [+] Less [-]English. Background: Melanin-targeting radiotracers are interesting tools for imaging and treatment of pigmented melanoma metastases. However, variation of the pigment concentration may alter the efficiency of such targeting.Objectives: A clear assessment of both tumor melanin status and dosimetry are therefore prerequisites for internal radiotherapy of disseminated melanoma.Materials & methods: The melanin tracer ICF01012 was labelled with iodine-123 for melanoma imaging in pigmented murine B16F0 and human SK-Mel 3 melanomas.Results: In vivo imaging showed that the uptake of [(123)I]ICF01012 to melanomas correlated significantly with melanin content. Schedule treatment of 3 × 25 MBq [(131)I]ICF01012 significantly reduced SK-Mel 3 tumor growth and significantly increased the median survival in treated mice. For this protocol, the calculated delivered dose was 53.2 Gy.Conclusion: Radio-iodinated ICF01012 is a good candidate for both imaging and therapeutic purposes for patients with metastatic pigmented melanomas.
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