Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: findings from the Childhood Leukaemia International Consortium (CLIC)
2019
Talibov, Madar | Olsson, Ann | Bailey, Helen | Erdmann, Friederike | Metayer, Catherine | Magnani, Corrado | Petridou, Eleni | Auvinen, Anssi | Spector, Logan | Clavel, Jacqueline | Roman, Eve | Dockerty, John | Nikkilä, Atte | Lohi, Olli | Kang, Alice | Psaltopoulou, Theodora | Miligi, Lucia | Vila, Javier | Cardis, Elisabeth | Schüz, Joachim | Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC) ; Organisation Mondiale de la Santé / World Health Organization Office [Genève, Suisse] (OMS / WHO) | Chesapeake Biological Laboratory (CBL) ; University of Maryland Center for Environmental Science (UMCES) ; University System of Maryland-University System of Maryland | Tampere University Hospital | Registre National des Cancers de l'Enfant - National Registry of Childhood Cancers [Villejuif & CHU Nancy] (RNCE) ; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)) ; Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent (CRESS - U1153) ; Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)) ; Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM) | Health Sciences ; University of York [York, UK] | Department of Clinical Therapeutics [Athens, Greece] ; National and Kapodistrian University of Athens (NKUA) | ISPO - Cancer Prevention and Research Institute ; Unit of Environmental and Occupational Epidemiology | Radiation Programme ; Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal)
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Show more [+] Less [-]English. Objectives: Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium.Methods: We pooled 11 case-control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated by linking jobs to an ELF-MF job-exposure matrix (JEM). Logistic regression models were used to estimate ORs and 95% CIs in pooled analyses and meta-analyses.Results: ORs from pooled analyses for paternal ELF-MF exposure >0.2 microtesla (µT) at conception were 1.04 (95% CI 0.95 to 1.13) for ALL and 1.06 (95% CI 0.87 to 1.29) for AML, compared with ≤0.2 µT. Corresponding ORs for maternal ELF-MF exposure during pregnancy were 1.00 (95% CI 0.89 to 1.12) for ALL and 0.85 (95% CI 0.61 to 1.16) for AML. No trends of increasing ORs with increasing exposure level were evident. Furthermore, no associations were observed in the meta-analyses.Conclusions: In this large international dataset applying a comprehensive quantitative JEM, we did not find any associations between parental occupational ELF-MF exposure and childhood leukaemia.
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