A human-curated annotation of the Candida albicans genome
2005
Braun, Burkhard | van Het Hoog, Marco | D'Enfert, Christophe | Martchenko, Mikhail | Dungan, Jan | Kuo, Alan | Inglis, Diane | Andrew Uhl, M. | Hogues, Hervé | Berriman, Matthew | Lorenz, Michael | Levitin, Anastasia | Oberholzer, Ursula | Bachewich, Catherine | Harcus, Doreen | Marcil, Anne | Dignard, Daniel | Iouk, Tatiana | Zito, Rosa | Frangeul, Lionel | Tekaia, Fredj | Rutherford, Kim | Wang, Edwin | Munro, Carol | Bates, Steve | Gow, Neil | Hoyer, Lois | Köhler, Gerwald | Morschhäuser, Joachim | Newport, George | Znaidi, Sadri | Raymond, Martine | Turcotte, Bernard | Sherlock, Gavin | Costanzo, Maria | Ihmels, Jan | Berman, Judith | Sanglard, Dominique | Agabian, Nina | Mitchell, Aaron | Johnson, Alexander | Whiteway, Malcom | Nantel, André | Department of Microbiology and Immunology ; University of California (UC) | Biotechnology Research Institute (Environmental Biotechnology Sector) ; National Research Council of Canada (NRC) | Biologie et Pathogénicité fongiques (BPF) ; Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP) | National Research Council of Canada (NRC) | Department of stomatology ; Universidade de São Paulo = University of São Paulo (USP) | The Wellcome Trust Sanger Institute [Cambridge] | University of Texas | Intégration et Analyse Génomique (Plate-Forme 4) (PF4) ; Institut Pasteur [Paris] (IP) | Génétique Moléculaire des Levures ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) | School of Medical Sciences ; University of Aberdeen | University of Illinois System | Julius-Maximilians-Universität Würzburg = University of Würzburg [Würsburg, Germany] (JMU) | Université de Montréal (UdeM) | McGill University = Université McGill [Montréal, Canada] | Sanford University School of Medecine ; Partenaires INRAE | Department of Molecular Genetics ; Weizmann Institute of Science [Rehovot, Israël] | Department of Genetics, Cell Biology and Development ; University of Minnesota [Twin Cities] (UMN) ; University of Minnesota System (UMN)-University of Minnesota System (UMN) | Institut de Microbiologie ; Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] (CHUV) | Columbia University [New York] | University of California [San Francisco] (UC San Francisco) ; University of California (UC)
International audience
Show more [+] Less [-]English. Recent sequencing and assembly of the genome for the fungal pathogen Candida albicans used simple automated procedures for the identification of putative genes. We have reviewed the entire assembly, both by hand and with additional bioinformatic resources, to accurately map and describe 6,354 genes and to identify 246 genes whose original database entries contained sequencing errors (or possibly mutations) that affect their reading frame. Comparison with other fungal genomes permitted the identification of numerous fungus-specific genes that might be targeted for antifungal therapy. We also observed that, compared to other fungi, the protein-coding sequences in the C. albicans genome are especially rich in short sequence repeats. Finally, our improved annotation permitted a detailed analysis of several multigene families, and comparative genomic studies showed that C. albicans has a far greater catabolic range, encoding respiratory Complex 1, several novel oxidoreductases and ketone body degrading enzymes, malonyl-CoA and enoyl-CoA carriers, several novel amino acid degrading enzymes, a variety of secreted catabolic lipases and proteases, and numerous transporters to assimilate the resulting nutrients. The results of these efforts will ensure that the Candida research community has uniform and comprehensive genomic information for medical research as well as for future diagnostic and therapeutic applications.
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