Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease
2013
Remy, Marie-Hélène | Merdes, Andreas | Gregory-Pauron, Lynn | Centre de biologie du développement (CBD) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI) ; Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) | Unité de Recherches Animal et Fonctionnalités des Produits Animaux (URAFPA) ; Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL) | Giraldo | J and Ciruela | F
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Show more [+] Less [-]English. Microtubules are among the main constituents of the cytoskeleton. They are assembled from dimers of alpha- and beta-tubulin. This assembly occurs preferentially at organizing centers such as the centrosomes, catalyzed by multiprotein complexes of gamma-tubulin. At the beginning of mitosis, the amount of gamma-tubulin complexes at the centrosomes increases sharply, supporting the sudden formation of numerous spindle microtubules. Recent studies on the structure of gamma-tubulin complex proteins have advanced our understanding of the assembly process of gamma-tubulin complexes, and have pointed toward putative mechanisms of microtubule nucleation. Moreover, the discovery of novel proteins associated with gamma-tubulin complexes has illustrated the possibilities of how gamma-tubulin might be recruited and regulated at specific sites of microtubule organization. This chapter highlights recent developments in the field and discusses the potential of the gamma-tubulin complex as a pharmacological target, to control proliferation of cells.
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