Internal dosimetry through GATE simulations of preclinical radiotherapy using melanin-targeting ligand
2014
Perrot, Y. | Degoul, F. | Auzeloux, P. | Bonnet, M. | Cachin, F. | Chezal, J.-M. | Donnarieix, D. | Labarre, P. | Moins, N. | Papon, J. | Rbah-Vidal, L. | Vidal, A. | Miot-Noirault, Elisabeth | Maigne, L. | Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC) ; Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) | Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP) ; UNICANCER | Imagerie Moléculaire et Thérapie Vectorisée (IMTV) ; Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Cancéropôle CLARA-ITMO " Technologies pour la Santé " | Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH) ; Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)
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Show more [+] Less [-]English. The GATE Monte Carlo simulation platform based on the Geant4 toolkit is under constant improvement for dosimetric calculations. In this study, we explore its use for the dosimetry of the preclinical targeted radiotherapy of melanoma using a new specific melanin-targeting radiotracer labeled with iodine 131. Calculated absorbed fractions and S values for spheres and murine models (digital and CT-scan-based mouse phantoms) are compared between GATE and EGSnrc Monte Carlo codes considering monoenergetic electrons and the detailed energy spectrum of iodine 131. The behavior of Geant4 standard and low energy models is also tested. Following the different authors' guidelines concerning the parameterization of electron physics models, this study demonstrates an agreement of 1.2% and 1.5% with EGSnrc, respectively, for the calculation of S values for small spheres and mouse phantoms. S values calculated with GATE are then used to compute the dose distribution in organs of interest using the activity distribution in mouse phantoms. This study gives the dosimetric data required for the translation of the new treatment to the clinic.
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