Perturbation of wool fibre cell differentiation by a mixture of bromodeoxyuridine and fluorodeoxyuridine
1991
Adelson, D.L. | Munro, S.G. | Tunks, D.A. (Commonwealth Scientific and Industrial Research Organisation, Blacktown (Australia). Div. of Animal Production)
Fibres from sheep injected with a mixture of 5-bromo-2'-deoxyuridine (BDU) and 5-fluoro-2'-deoxyuridine (FDU) exhibited both abnormal cuticle scale patterns and disorganized ortho- and paracortex. Using a monoclonal antibody specific for orthocortical cells it was determined that the normal pattern of orthocortical cell differentiation was reversibly inhibited by BDU-FDU treatment and fibre length growth rate was reversibly decreased very slightly. It was concluded that BDU-FDU can grossly perturb aspects of wool follicle bulb cell differentiation without profoundly affecting fibre length growth rate.
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