The distribution of soluble copper- and zinc-binding proteins in goat liver [liver proteins]
1979
Mjoer-Grimsrud, M. (Veterinaerinstituttet, Oslo (Norway)) | Soeli, N.E. | Sivertsen, T.
The distributions of copper and zinc in the soluble proteins from goat liver after gel filtration were determined. Samples from normal slaughtered animals as well as from experimentally copper-loaded goats were tested. The copper- and zinc-binding proteins were mainly separated into 3 different fractions. The approximate molecular weights were 65,000,35,000 and 10,000. Varying amounts of zinc were eluted in a fourth fraction of molecular weight less than 2000. The results indicate that the distribution of copper and zinc among soluble metal-binding proteins are higly dependent on the total liver zinc concentration. In the majority of samples, with zinc levels within 20 to 45 mu.g/g wet weight, the dominating copper-and zinc-binding protein fraction was the high-molecular weight fraction. This did not seem to be influenced by the total liver copper level. In the samples with high total liver zinc levels (60 mu.g/g w.w.) there was shift in protein distribution of both metals toward the low-molecular weight fractions.
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