The possible role of water pollutants in the aetiology of malignant lymphoma in the northern pike Esox lucius L. [pollution, chemicals, epizootiology, virology, viral aetiology, Baltic Sea, Canada, USA, Ireland]
1980
McIntyre, A.D. (Marine Lab., Aberdeen (UK)) | Pearce, J.B. (eds.) | Mulcahy, M.F.
Malignant lymphoma occurs in feral northern pike Esox lucius L. It takes the form of cutaneous neoplastic growths, often massive, primarily from the jaws, flank or fin bases. Epizootics of the disease have been reported from Ireland, the Baltic Sea, Canada and northern USA with incidence up to 20.9 per cent; between epizootics the disease may be undetectable. There is evidence for viral aetiology: the disease has been experimentally transmitted by cell-free filtrates, and virus particles and reverse transcriptase activity in fractionated tumour cells have been reported. The neoplasm is most prevalent in the Baltic and in northern USA in regions of significant pollution, although epizootics have occurred in the absence of obvious chemical pollution in Ireland and in Canada. Genetic, seasonal, age and immunological factors are also known to influence the occurrence of the disease. The available evidence from studies to date suggest that, in pike lymphoma, pollutant chemicals may play an enhancing role in a viral aetiology
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