Enhancement of bone healing using non‐glycosylated rhBMP‐2 released from a fibrin matrix in dogs and cats
Schmoekel, H. G. | Weber, F. E. | Hurter, K. | Schense, J. C. | Seiler, G. | Rytz, U. | Spreng, D. | Schawalder, P. | Hubbell, J.
Objectives: To test a non‐glycosylated recombinant human bone morphogenetic protein‐2 (ngly‐rhBMP‐2)/fibrin composite, which has been shown experimentally to enhance healing of bone defects in rodents, in a clinical case series of dogs and cats undergoing treatment for fracture non‐unions and arthrodesis. Methods: A ngly‐rhBMP‐2/fibrin composite was applied in 41 sites in 38 dogs and cats for which a cancellous bone autograft was indicated, replacing the graft. Results: Bridging of the bone defect with functional bone healing was achieved in 90 per cent of the arthrodesis and fracture nonunions treated in this manner. Clinical Significance: This prospective clinical study demonstrates the beneficial effects of ngly‐rhBMP‐2 in a specially designed fibrin matrix on the treatment of bone defects, and validates the use of this composite as an alternative to bone autografts in dogs and cats.Show more [+] Less [-]