Lewis Acid Catalyzed Intramolecular Condensation of Ynol Ether-Acetals. Synthesis of Alkoxycycloalkene Carboxylates
Tran, Vincent | Minehan, Thomas G.
Treatment of ynol ether-tethered dialkyl acetals with catalytic quantities of scandium triflate in CHâCN gives rise to five-, six-, and seven-membered alkoxycycloalkene carboxylates in good to excellent yields. Tri- and tetrasubstituted carbocyclic and heterocyclic alkenes may be formed by this method, and the products obtained may serve as useful intermediates for natural product synthesis.Show more [+] Less [-]