Correlation between oral fluid and plasma oxytetracycline concentrations after intramuscular administration in pigs
Gajda, A. | Jablonski, A. | Gbylik â Sikorska, M. | Posyniak, A.
The penetration of oxytetracycline (OTC) into the oral fluid and plasma of pigs and correlation between oral fluid and plasma were evaluated after a single intramuscular (i.m.) dose of 20Â mg/kg body weight of longâacting formulation. The OTC was detectable both in oral fluid and plasma from 1Â hr up to 21Â day after drug administration. The maximum concentrations (Câââ) of drug with values of 4021Â Â±Â 836Â ng/ml in oral fluid and 4447Â Â±Â 735Â ng/ml in plasma were reached (Tâââ) at 2 and 1Â hr after drug administration respectively. The area under concentrationâtime curve (AUC), mean residence time (MRT) and the elimination halfâlife (tâ/âáµ¦) were, respectively, 75613 ngÂ ÃÂ hr/ml, 62.8Â hr and 117Â hr in oral fluid and 115314 ngÂ ÃÂ hr/ml, 31.4Â hr and 59.2Â hr in plasma. The OTC concentrations were remained higher in plasma for 48Â hr. After this time, OTC reached greater level in oral fluid. The strong correlation (rÂ =Â .92) between oral fluid and plasma OTC concentrations was observed. Concentrations of OTC were within the therapeutic levels for most sensitive microâorganism in pigs (above MIC values) for 48Â hr after drug administration, both in the plasma and in oral fluid.Show more [+] Less [-]