Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2

Hrstka, Roman; Murray, Euan; Brychtova, Veronika; Fabian, Pavel; Hupp, Ted R.; Vojtesek, Borivoj

Identification of an AKT-dependent signalling pathway that mediates tamoxifen-dependent induction of the pro-metastatic protein anterior gradient-2

2013

The pro-metastatic protein anterior gradient-2 (AGR2) was previously demonstrated as a predictive factor of poor response to tamoxifen treatment. In this study we aimed to delineate the key signalling pathway that may contribute to regulation of AGR2 protein induction in order to identify novel targets to overcome tamoxifen resistance in tumour cells. Together, our data identify PDPK1-AKT as a pro-oncogenic signalling pathway that triggers AGR2 protein induction in response to tamoxifen and suggest that AKT inhibitors could be used as part of a therapeutic strategy to treat tamoxifen resistant, AGR2 over-expressing cancers.

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AGROVOC Keywords

antineoplastic agents drug resistance drug therapy genetics humans metabolism neoplasms pathology pharmacology proteins proteins ribonucleosides serine

Bibliographic information

Published in

Cancer letters

ISSN 0304-3835

Publisher

Elsevier B.V.

Other Subjects

Breast neoplasms; 3-phosphoinositide-dependent protein kinases; Tamoxifen; Signal transduction; Tamoxifen; Female; Micrornas; Drug effects; Signal transduction; Proto-oncogene proteins c-akt; Cell line; Tumor; Molecular sequence data; Protein serine-threonine kinases; Base sequence; Hormonal

Language

English

Type

Text; Journal Article

In AGRIS since: 2024-02-27

Format: MODS

Data Provider

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Links

DOI http://dx.doi.org/10.1016/j.canlet.2013.01.034

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