2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists
2013
Andrés, Miriam | Bravo, Mónica | Buil, Maria Antonia | Calbet, Marta | Castro, Jordi | Domènech, Teresa | Eichhorn, Peter | Ferrer, Manel | Gomez, Elena | Lehner, Martin D. | Moreno, Imma | Roberts, Richard S. | Sevilla, Sara
High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR but also identified some low nanomolar inhibitors.
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