Assessment of the pectolinarin content and the radical scavenging-linked antiobesity activity of Cirsium setidens Nakai extracts
2015
Lee, Young-Jun | Lee, Jin Ha | Kim, Young-Hyun | Kim, Jae-Hwan | Yu, Seok-Yeong | Kim, Dan-Bi | Lee, Jong Seok | Cho, Myoung Lae | Cho, Ju-Hyun | Kim, Bong Kyun | Lee, Boo-Yong | Lee, Ok-Hwan
Cirsium setidens Nakai contains bioactive compounds that exert biological activities. Method validation for analysis of the pectolinarin content in Cirsium setidens extracts (CSE) and radical scavenging-linked antiobesity activities using 3T3-L1 cells and C57BL/6 mice were performed. The pectolinarin content of CSE was 2.81±0.01 mg/g with a high degree of linearity in calibration curves (R ²=0.9999). CSE exhibited free radical-scavenging activities and a reducing power. CSE and pectolinarin inhibited lipid accumulation during adipogenesis of 3T3-L1 cells via down-regulation of adipogenic transcription factors. CSE supplementation suppressed body weight in C57BL/6 mice fed a high fat diet and reduced plasma total cholesterol, triglyceride, insulin, and glucose levels. Pectolinarin-enriched CSE can be considered as a good source of natural antioxidants and antiobesity ingredients.
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