Tailoring the P450 Monooxygenase Gene for FR-008/Candicidin Biosynthesis
2009
Chen, Shi | Mao, Xiangzhao | Shen, Yaling | Zhou, Yongjun | Li, Jialiang | Wang, Lianrong | Tao, Xinyi | Yang, Liang | Wang, Yuxiao | Zhou, Xiufen | Deng, Zixin | Wei, Dongzhi
Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin.
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