Acetyl and butyrylcholinesterase-inhibiting triterpenoid alkaloids from Buxus papillosa
2001
Atta-Ur-Rahman. | Parveen, S. | Khalid, A. | Farooq, A. | Choudhary, M.I.
Three triterpenoid alkaloids, buxakashmiramine [(20S)-20-dimethylamino-4', 6'-dimethoxy-5'-hydroxybenzoylamino-3 beta-methyl-buxan-31-ol] (1), buxakarachiamine [(20S)-20-dimethylamino-2'-hydroxy-3 beta-methyl-3'-methyl-butanoylamino-9,10-seco-buxa-9(11), 10(19)-dien-31-ol] (2) and buxahejramine [(20S)-20-dimethylamino-2'-hydroxy-3 beta-methyl-3'-methyl-pentanoylamino-9,10-seco-buxa-9(11), 10(19)-dien-31-ol] (3) were isolated from the leaves of Buxus papillosa. Four known bases, cycloprotobuxine-C (4), cyclovirobuxeine-A (5), cyclomicrophylline-A (6) and semperviraminol (7) were isolated for the first time from this species. Their structures were established through extensive spectroscopic studies. Most of these compounds exhibited anticholinesterase activity.
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