Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A
2017
Hu, Zhengxi | Wu, Ye | Xie, Shuangshuang | Sun, Weiguang | Guo, Yi | Li, Xiao-Nian | Liu, Junjun | Li, Hua | Wang, Jianping | Luo, Zengwei | Xue, Yongbo | Zhang, Yonghui
Two new functionalized ergostane-type steroids, phomopsterones A (1) and B (2), were isolated from the plant-derived Phomopsis sp. TJ507A. Their structures were determined on the basis of spectroscopic data, a modified Mosher’s method, X-ray crystallographic analysis, and quantum chemical calculations. Compound 1 is an unprecedented ergosteroid featuring a rearranged bicyclo[3.3.1]nonane motif resulting from B-ring scission and a subsequent 180° rotation of the ring A during biosynthesis. Compound 2 exhibited anti-inflammatory activity.
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