Efficient synthesis of 5-substituted-3-pyridazine carbonitrile via regioselective Reissert-type reaction
2016
Wang, Shengqiang | Geng, Zhiyue | Guo, Ruiyun | Li, Jingya | Zou, Dapeng | Wu, Yangjie | Wu, Yusheng
Various 5-substituted-3-pyridazine carbonitrile derivatives were synthesized by regioselective Reissert-type reaction with 4-substituted pyridazine, 4-methylbenzene-1-sulfonyl chloride and trimethylsilyl cyanide. The reaction can be carried out under conditions of AlCl3 as catalyst, THF as solvent at 10°C, followed by treatment with DBU which gave moderate yields and good regioselectivity.
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