Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase

Chen, Xian-Qiang; Zhao, Jing; Chen, Ling-Xiao; Wang, Shen-Fei; Wang, Ying; Li, Shao-ping

Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase

2018

Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time. The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-oxo-ganoderic acid Z3, 7-oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose. The structure-activity relationships of ganoderma triterpenes on α-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes.

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AGROVOC Keywords

alpha-glucosidase drugs ganoderma mushrooms spectral analysis

Bibliographic information

Published in

Phytochemistry

Volume 149 Pagination 103 - 115 ISSN 0031-9422

Publisher

Elsevier Ltd

Other Subjects

Duxffvyodrxepm-hxmophlfsa-n; Zwmmekxolcckla-ukqseqlysa-n; Sxbokjlqzqavpu-mrrhukjasa-n; Xcoztxyrnztfeu-aewpqsqusa-n; Kihvgbmpkkdqcu-qxaxhbffsa-n; Vfcvarjmdqznkd-sgisufrfsa-n; Gwxyuytzjnwgad-gouakddgsa-n; Lijzgbvdqctwlg-kjicsubbsa-n; Structure-activity relationships; Zwsbrgideiyqsk-gkgamfjcsa-n; Cufbldxhawkojf-rhhcxwcysa-n; Ganoderma resinaceum; Lnmglkyhdazcda-kyngrmobsa-n; Oahmoixuymvemu-oebbvkddsa-n; Uwdvmoljnpvfqa-gnmirfeqsa-n; Ksjxbrqbevkvdr-rscsfwrxsa-n; Lwplehfgbrfrki-xdbgzbgesa-n; Azpoacudfjkuhj-woxsliatsa-n; Qbaaqlpbkjnuhf-yzvzlejisa-n; Rzbiluatlyxzli-sldnwhahsa-n; Enzyme inhibition; Dwwldqkkmgmdqg-kiclkpqxsa-n; Aoxxvrdkzlrgtj-saxmsosvsa-n; Hutcyujplotdmx-boskrlfksa-n; Chemical bonding; Jicyaovvidykjq-qksmpbitsa-n; Fruiting bodies; Acarbose; Bltrpnnwbnkaeh-pmwlthjjsa-n; Azcyoybnouoojj-bkgkkvrwsa-n; Zoazkojqevtdkv-itjzhyoksa-n; Gfijhppdzldbqt-khvfmcdzsa-n; Btytwxwafwksta-zgrqbdoqsa-n; Sxbokjlqzqavpu-zdextqrrsa-n; Izuvoownbdydkf-ybxxxjdpsa-n; Α-glucosidase inhibitor; Xowzegqxfdyeeb-owcjgcgpsa-n; Ojqdqvklmqpwjl-stsloysgsa-n; Ganoderic acid; Rrzcijoexyrbdw-xytnwhglsa-n; Dieuzipsdugwld-ozcpjkkfsa-n; Oxpoitnfzzpvlk-uebcxajfsa-n; Ganodermataceae; Rdzrnuxqsvyshw-ncbroptrsa-n; Fwdqernwskuhaw-lkykqubpsa-n; Lanostane triterpenes; Mlbftspqzalzah-iccngfossa-n; In vitro studies; Cwkrzzxkjfndbt-xemztadasa-n; Bezwxqqeevuvpy-dumfznbjsa-n; Qecqjyaiiiikjb-rlebvhdzsa-n; Jupxtlomxspqgx-joxscumjsa-n; Zndcxcgtaalltp-qmhrwallsa-n; Aajihhyephriet-jnahjfnhsa-n; Cwkrzzxkjfndbt-prgjfqoksa-n; Camfafmggcbmjc-vsbyuqrcsa-n; Vycvqrqgznghfr-jznowyatsa-n; Nmcafqwjqypxbs-uonacnnisa-n; Pioybulrrjnpsg-woxsliatsa-n

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-27

Format: MODS

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This bibliographic record has been provided by National Agricultural Library

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Links

DOI DOI https://dx.doi.org/10.1016/j.phytochem.2018.01.007

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