Preparation of isoindolinones via a palladium-catalyzed diamination
2017
Li, Yu | Kou, Xuezhen | Ye, Chenghao | Zhang, Xinghua | Yang, Guoqiang | Zhang, Wanbin
A Pd(II)-catalyzed cyclization using oxidative olefin diamination was developed for the preparation of isoindolinones from ortho-olefinic N-methoxybenzamides. Using the optimized reaction conditions, the desired products were obtained in up to 90% yield using NFSI as the oxidant. This reaction provides an efficient and direct access to isoindolinones with amine functionality, an important drug skeleton.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library