Rhodium(III) Catalyzed Carboamination of Alkenes Triggered by C–H Activation of N-Phenoxyacetamides under Redox-Neutral Conditions
2016
Hu, Zhiyong | Tong, Xiaofeng | Liu, Guixia
N-Alkoxyacrylamides are coupled with N-phenoxyacetamides by Rhᴵᴵᴵ catalysis through C–H functionalization and amido group transfer under external oxidant-free conditions, which affords acyclic alkene carboamination products in an atom-economical way. Mechanistic insight into this transformation indicates the amide group in N-alkoxyacrylamide plays a critical role in this C–C/C–N bond formation reaction. This methodology provides a highly efficient way to construct o-tyrosine derivatives under mild conditions.
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