Differential resistance to Staphylococcus aureus challenge in major histocompatibility (B) complex congenic lines
1992
Cotter, P.F. | Taylor, R.L. Jr | Abplanalp, H.
Ten inbred B-congenic Leghorn lines were challenged with two isolates of Staphylococcus aureus at 3 days and 6 wk of age. Significant differences in mortality were observed among such lines when challenged at 3 days with either S. aureus Isolate P4L (moderately pathogenic) or S. aureus Isolate 3727 (highly pathogenic). Line 331 (B(2)/B(2) genotype) had lower mortality than either Line 004 (B(17)/B(17), chi(2) = 4.13, P less than .05) or Line 253 (B(18) B(18) chi(2) = 4.23, P less than .05) challenged with Isolate P4L. The use of a susceptibility index allowed for the detection of additional differences among the various lines challenged by Isolate 3727. Line 336 (B(Q)/B(Q)) was more resistant than either Line 335 (B(19)/B(19) P less than.01) or Line 330 (B(21)/B(21), p less than .01). No significant differences were found among the lines challenged at 6 wk by either isolate. The results provide additional evidence for the importance of the B complex in genetically determined disease resistance, and further demonstrate the usefulness of congenic lines in such investigations.
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