Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation
2011
Odajima, Junko | Wills, Zachary P. | Ndassa, Yasmine M. | Terunuma, Miho | Kretschmannova, Karla | Deeb, Tarek Z. | Geng, Yan | Gawrzak, Sylwia | Quadros, Isabel M. | Newman, Jennifer | Das, Manjusri | Jecrois, Marie E. | Yu, Qunyan | Li, Na | Bienvenu, Frederic | Moss, Stephen J. | Greenberg, Michael E. | Marto, Jarrod A. | Siciński, Piotr
Cyclin E is a component of the core cell cycle machinery, and it drives cell proliferation by regulating entry and progression of cells through the DNA synthesis phase. Cyclin E expression is normally restricted to proliferating cells. However, high levels of cyclin E are expressed in the adult brain. The function of cyclin E in quiescent, postmitotic nervous system remains unknown. Here we use a combination of in vivo quantitative proteomics and analyses of cyclin E knockout mice to demonstrate that in terminally differentiated neurons cyclin E forms complexes with Cdk5 and controls synapse function by restraining Cdk5 activity. Ablation of cyclin E led to a decreased number of synapses, reduced number and volume of dendritic spines, and resulted in impaired synaptic plasticity and memory formation in cyclin E-deficient animals. These results reveal a cell cycle-independent role for a core cell cycle protein, cyclin E, in synapse function and memory.
Show more [+] Less [-]AGROVOC Keywords
Bibliographic information
This bibliographic record has been provided by National Agricultural Library